All Articles Tagged As: vaccines

Pakistan introduces vaccine to prevent top child killer (11/5/2008)

5 million children each year to receive their first shot of pentavalent vaccine ...> Full Article

Researchers develop safer, more effective TB vaccine for HIV-positive people (10/30/2008)

TB is the leading cause of death worldwide for HIV-positive individuals ...> Full Article

Bird flu vaccine protects people and pets (10/21/2008)

A single vaccine could be used to protect chickens, cats and humans against deadly flu pandemics ...> Full Article

New vaccines may not reduce TB incidence (10/8/2008)

Despite the potential of new vaccines to prevent TB, new research shows that the removal of one strain of TB can allow a previously suppressed strain to succeed. Consequently, a vaccination program could result in the proliferation of strains more likely to be, or become, drug resistant, and could even result in an increased prevalence of the disease. ...> Full Article

Novel tuberculosis vaccine in Germany in clinical phase (9/15/2008)

For the first time in more than 80 years a promising live vaccine against tuberculosis has passed into the clinical phase in Germany ...> Full Article

Scientists Receive $3.6 Million to Test Vaccine Against Deadliest Strain of Avian Flu (8/29/2008)

Scientists at the University of Pittsburgh Center for Vaccine Research have been awarded $3.6 million from the National Institute of Allergy and Infectious Diseases to conduct animal studies of vaccines designed to protect against the most common and deadliest strain of avian flu, H5N1. ...> Full Article

Rare Case In A Baltimore Couple Explains Why Some Infected With Hiv Remain Symptom Free For Years Without Antiretroviral Drugs (8/13/2008)

Finding renews promise of vaccine against AIDS; disproves theory of defective virus ...> Full Article

Professor develops vaccine to protect against black plague bioterror attack (8/3/2008)

Oral vaccine combats various versions of the plague ...> Full Article

Plants make vaccine for treating type of cancer (7/23/2008)

Plants could act as safe, speedy factories for growing antibodies for personalized treatments against a common form of cancer ...> Full Article

Researchers use salmonella as a way to administer vaccines in the body (7/15/2008)

Researchers have made a major step forward in their work to develop a biologically engineered organism that can effectively deliver an antigen in the body ...> Full Article

Parasite vaccines within reach (7/6/2008)

Even though parasites are complex creatures, the mammalian immune response to them is surprisingly simple, leading researchers to predict that creating vaccines for parasitic diseases such as malaria may be more straightforward than initially thought. ...> Full Article

New DNA Weapon Against Avian Flu (7/5/2008)

Broad Application of DNA Vaccine Could Allow for Quick Mobilization During an Epidemic ...> Full Article

Yeast-Based Vaccine Reduces Tumor Size (7/2/2008)

Scientists have found that vaccination with a heat-killed, nontoxic yeast that is genetically engineered to manufacture a common tumor protein can induce specific and repeated anti-tumor immune responses in mice. Vaccination extends overall survival and reduces tumor size in mice that have been injected with cancer cells displaying the same protein that was engineered into the yeast. ...> Full Article

New Approach to HIV Vaccine Research (6/28/2008)

A new national effort to create a vaccine against HIV will include work by a University of Rochester Medical Center rheumatologist who is an expert on a portion of the immune system that has sometimes gotten short shrift in the fight against HIV. ...> Full Article

A protein sequence associated with Huntington's disease may become life-saving vaccine component (6/13/2008)

Protein sequence important in neurodegenerative Huntington's disease can be safely used as a new generation of vaccine adjuvants. ...> Full Article

Study Finds Unique HIV Vaccine Formula Elicits Strong Immune Responses (5/27/2008)

Investigators express hope for HIV vaccine research with an alternative strategy ...> Full Article

Researchers Describe How Vaccine Adjuvant Jump-Starts Immune System (5/24/2008)

Researchers have determined how a key component of many vaccines activates an immune system response, a finding that opens up promising new avenues of research on better ways to prevent infections. ...> Full Article

Researchers make West Nile vaccine breakthrough (5/22/2008)

Researchers have made a giant leap forward in the race to develop a vaccine for the potentially debilitating West Nile virus ...> Full Article

DNA vaccines get a boost from dendritic cells (5/20/2008)

Researchers targeting HIV antibody proteins directly to the coordinating cells of the immune system. ...> Full Article

Researcher Receives $2.6 Million to Develop Vaccine Against Ebola Virus (5/3/2008)

Dr. Maria Croyle, associate professor of pharmaceutics at The University of Texas at Austin College of Pharmacy, has received $2.6 million to develop a vaccine against Ebola virus infection. ...> Full Article

New vaccine may give long-term defense against deadly bird flu and its variant forms (4/29/2008)

A new vaccine under development may provide protection against highly pathogenic bird flu and its evolving forms ...> Full Article

Discovery to hasten new malaria treatments, vaccines for children (4/27/2008)

Biologists have discovered an autoimmune-like response in blood drawn from malaria-infected African children that helps to explain why existing DNA-based anti-malaria vaccines have repeatedly failed to protect them. ...> Full Article

New technology for boosting vaccine efficiency (4/27/2008)

One of the most pressing biomedical issues is the development of techniques that increase the efficiency of vaccines ...> Full Article

Researchers Discover Anti-virulence Factor in Salmonella (4/6/2008)

Researchers have discovered an anti-virulence factor in Salmonella, knowledge that could be used to design improved Salmonella vaccines. ...> Full Article

Vaccine for Ebola virus (4/2/2008)

One of the world's deadliest diseases, caused by the Ebola virus, may finally be preventable thanks to US and Canadian researchers, who have successfully tested several Ebola vaccines in primates and are now looking to adapt them for human use. ...> Full Article

Modified Virus Vaccine Shows Breast Cancer Promise (3/18/2008)

Researchers have shown that vaccinating mice with a modified form of a virus containing proteins from breast cancer cells can kill large breast cancer tumors and tumors that have spread to the lungs. The rodent model of cancer used in this study closely resembles a type of breast cancer seen in humans called HER2-positive. Although other cancer vaccines have shown activity in the treatment of very small tumors, their ability to influence large, established tumors, such as many HER2-positive breast cancers, has proven difficult. The study, led by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, appeared in the March 15, 2008, issue of Cancer Research. ...> Full Article

Inhaled tuberculosis vaccine more effective than traditional shot (3/14/2008)

A novel aerosol version of the most common tuberculosis (TB) vaccine, administered directly to the lungs as an oral mist, offers significantly better protection against the disease in experimental animals than a comparable dose of the traditional injected vaccine, researchers report this week in the Proceedings of the National Academy of Sciences. ...> Full Article

HPV Vaccine for Men? (3/6/2008)

New vaccine used to prevent sexually transmitted human papillomavirus (HPV) in women and girls could play the same role in men and boys ...> Full Article

Tumor Vaccines Developed by Researchers (3/4/2008)

A new study reveals how Keck School researchers have discovered a new molecular player that will help create a better vaccination against tumors. ...> Full Article

Seeing small, thinking big (2/19/2008)

Microbiologist Marc Jenkins is tracking the movements of immune system cells with an eye to developing vaccines, preventing organ transplant rejection and combating autoimmune diseases. Cell biologist Mary Porter is studying the molecular motors that move substances along the highways within cells, a function critical to development and function of organs and even entire organisms. Timothy Ebner, professor and head of neuroscience, is studying how brain circuits work in the areas of the brain that control movements, and how these circuits malfunction in neurological disease. ...> Full Article

New picture of HIV-1's protein jacket identifies attractive target for antibody-based vaccine (2/16/2008)

By coaxing the HIV-1 protein to reveal a hidden portion of its protein coat, scientists at Dana-Farber Cancer Institute and Harvard Medical School have provided a newly detailed picture of how protective, or so-called broadly neutralizing, antibodies block HIV-1 infection. ...> Full Article

Experimental HIV vaccine gets a boost from '70s-era discovery (2/14/2008)

Although science is known for being a forward-looking field, researchers have found that they can often benefit from a glance over their shoulders. By combining an experimental AIDS vaccine with a long-neglected molecule called poly-IC, Rockefeller University scientists discovered that they were able to significantly improve its effectiveness. Their new, bolstered vaccine not only stimulated the production of HIV-attacking immune cells in mice, but also allowed the rodents to maintain immunity over a significantly longer period of time. ...> Full Article

Novel Molecules Developed at UB Can Boost Vaccine Potency (2/6/2008)

Two novel proteins studied by a University at Buffalo professor of microbiology and immunology appear to have the potential to enhance the production of antibodies against a multitude of infectious agents. ...> Full Article

Malaria vaccine trials begin using 'chimpanzee virus' (2/4/2008)

Trials are underway for a new vaccine to combat the most deadly form of malaria. For the first time ever, researchers will use a virus found in chimpanzees to boost the efficacy of the vaccine. The trials will take place at the University of Oxford's Jenner Institute, led by its Director, Professor Adrian Hill, and are funded by the Wellcome Trust. ...> Full Article

New Insights Into Vaccination For HIV (2/3/2008)

A group of Australian researchers at the Universities of Melbourne and New South Wales have developed new tools and paradigms to understand immune evasion from HIV. The study shows that both prior vaccination and timing influence the rates of immune escape, providing further insight into the effectiveness of T cell immunity to HIV. ...> Full Article

New Vaccine against Deadliest Strain of Avian Flu Tested by Scientists (2/1/2008)

New Vaccine against Deadliest Strain of Avian Flu Tested by University of Pittsburgh Scientists ...> Full Article

Early Promising Results in Malaria Vaccine Trial in Mali (1/27/2008)

A small clinical trial conducted by an international team of researchers in Mali has found that a candidate malaria vaccine was safe and elicited strong immune responses in the 40 Malian adults who received it. The trial was the first to test this vaccine candidate, which is designed to block the malaria parasite from entering human blood cells, in a malaria-endemic country. Based on these promising results, the research team is now conducting trials of this vaccine in 400 Malian children aged 1 to 6 years. Malaria is a leading killer in Africa and other developing countries, claiming more than 1 million lives each year, most of them children. ...> Full Article

Newer Meningitis Vaccine Appears Safe And Effective For Infants (1/11/2008)

Vaccine not yet licensed in the United States produces immunity against four strains of meningococcal disease and is well tolerated when administered to infants, according to a study in the January 9/16 issue of JAMA. ...> Full Article

Smallpox vaccine alternative identified (1/8/2008)

Modified vaccinia virus shows potential to replace current biodefense vaccine stockpile ...> Full Article

Researchers Train the Immune System to Deliver Virus that Destroys Cancer in Lab Models (12/20/2007)

An international team of researchers led by Mayo Clinic have designed a technique that uses the body's own cells and a virus to destroy cancer cells that spread from primary tumors to other parts of the body through the lymphatic system. In addition, their study shows that this technology could be the basis for a new cancer vaccine to prevent cancer recurrence. ...> Full Article

Molecular 'trip switch' shuts down inflammatory response (12/19/2007)

Like a circuit breaker that prevents electrical wiring from overheating and bringing down the house, a tiny family of three molecules stops the immune system from mounting an out-of-control, destructive inflammatory response against invading pathogens, researchers at the Salk Institute for Biological Studies have found. ...> Full Article

Study shows cholera can be controlled with oral vaccines (11/27/2007)

Endemic cholera, a potentially fatal diarrheal disease found in the world's most impoverished countries, could be effectively controlled by orally vaccinating half of the affected populations once every two years for only pennies per dose. ...> Full Article

Researchers Find Monkeys Able to Fend Off AIDS-like Symptoms with Enhanced HIV Vaccine (11/22/2007)

Researchers have discovered that using an immune system gene to enhance a vaccine used to study HIV in macaque monkeys provides the animals with greater protection against simian HIV (SHIV) than an unmodified vaccine. This multi-year study found that the addition of a molecule called Interleukin-15 effectively boosts the effects of a vaccine derived from the DNA of simian HIV. The study illustrates that DNA vaccine effectiveness can be improved by the inclusion of specific immune adjuvants, or helpers. ...> Full Article

Mushrooms may aid rapid vaccine response (11/21/2007)

A rapid production of therapeutic human drugs using modified mushrooms may help mount a quicker response to various public health problems, according to plant pathologists who have received a federal grant to perfect their technique. ...> Full Article

New HPV vaccine under study (11/21/2007)

A new vaccine against nine of the most harmful strains of human papillomavirus is under study at the Medical College of Georgia. ...> Full Article

Virus Used to Create Experimental HIV Vaccines Directly Impairs the Immune Response (11/19/2007)

Leading efforts to create an HIV vaccine have hinged on the use of viruses as carriers for selected elements of the HIV virus. Recently, however, evidence has emerged that some of these so-called viral vector systems may undermine the immune system and should not be used for vaccine development. Now, a new study from scientists at The Wistar Institute provides strong support for the idea that some viral-vector vaccines may cause more harm than good. ...> Full Article

A Dose of Radiation May Help Knock Out Malaria (11/14/2007)

How are physicists helping an effort to eradicate malaria, the mosquito-borne disease that kills more than one million people every year? Physicists used their expertise in radiation science to help a young company create weakened, harmless versions of the malaria-causing parasite. These parasites, in turn, are being used to create a new type of vaccine that shows promise of being more effective than current malaria vaccines. ...> Full Article

Pitt Researchers Receive Grants to Develop Dengue Fever Vaccine (11/8/2007)

The Center for Vaccine Research (CVR) at the University of Pittsburgh has received two grants totaling $4.8 million from the U.S. Department of Defense to develop a new vaccine strategy for dengue fever. A major public health issue worldwide, dengue fever is caused by a virus that is a close relative to West Nile virus. The award will allow researchers Ted M. Ross, Ph.D., assistant professor, University of Pittsburgh School of Medicine, and Donald S. Burke, M.D., professor and dean, University of Pittsburgh Graduate School of Public Health and CVR director, to improve survival outcomes for people infected with dengue fever. ...> Full Article

Salmonella-based vaccine named as finalist (11/3/2007)

A Biodesign Institute research initiative aimed at advancing global health through the development of new vaccines has been selected as a finalist for the annual Governor's Council of Innovation Awards. ...> Full Article

Researchers one step closer to cancer vaccine (10/31/2007)

When cells become cancerous, the sugars on their surfaces undergo distinct changes that set them apart from healthy cells. For decades, scientists have tried to exploit these differences by training the immune system to attack cancerous cells before they can spread and ravage the body. ...> Full Article

Researchers test novel vaccine to treat aggressive brain tumors (10/28/2007)

New vaccine for glioblastoma multiforme, an aggressive brain cancer, is now being offered through a clinical trial at Mayo Clinic in Jacksonville. ...> Full Article

Projected supply of pandemic influenza vaccine sharply increases (10/24/2007)

Recent scientific advances and increased vaccine manufacturing capacity have prompted experts to increase their projections of how many pandemic influenza vaccine courses can be made available in the coming years. ...> Full Article

Researchers seek volunteers for malaria vaccine study (10/19/2007)

The experimental malaria vaccine uses a type of adenovirus that does not usually infect humans, so people receiving the vaccine should not have any immune response. ...> Full Article

Matching Pathogens To Their Antibodies: Could Lead To HIV Vaccine (10/18/2007)

The search for a vaccination against HIV has been in progress since 1984, with very little success. Traditional methods used for identifying potential cellular targets can be very costly and time-consuming. ...> Full Article

'Enterprizing' vaccine for Rheumatoid Arthritis (10/7/2007)

Enterprize finalist, Dendright, will be pitching its vaccine technology for rheumatoid arthritis to venture capitalists and the public for a $100,000 prize next week. ...> Full Article

Innovative dual action anthrax vaccine-antitoxin combination (10/6/2007)

Researchers develop a highly effective agent that provides protection against anthrax by combining a fast-acting anthrax toxin inhibitor with a vaccine in a single compound. ...> Full Article

Researchers show first results from new Epstein Barr cancer vaccine (10/4/2007)

Researchers are using a vaccination for a common virus as a way of stimulating the body's immune system to attack cancer cells. ...> Full Article

Immunizations Are Discontinued in Two HIV Vaccine Trials (9/24/2007)

HIV Vaccine trials canceled after participants taking the vaccines became infected with HIV at a higher rate than those participants taking a placebo. ...> Full Article

Impact of New Cancer Vaccine to be Evaluated in Rochester (9/20/2007)

Rochester has been chosen as one of four national sites to monitor the effectiveness of the new cervical cancer vaccine. The project, which is funded by the national Centers for Disease Control and Prevention (CDC), will be jointly conducted by the University of Rochester Medical Center (URMC) and the New York State Department of Health. ...> Full Article

Possible Hepatitis C Vaccine (9/7/2007)

Hepatitis C Virus (HCV) infects up to 500,000 people in the UK alone, many of the infections going undiagnosed. It is the single biggest cause of people requiring a liver transplant in Britain. Now, in a collaborative effort with groups across Europe and the USA, scientists from The University of Nottingham have found monoclonal antibodies which may be a significant step towards a vaccine. ...> Full Article

Human Papilloma Virus Vaccines May Decrease Chances Of Oral Cancer (9/2/2007)

The Centers for Disease Control report that nearly 25 million women are infected with some form of the Human Papilloma Virus (HPV). Of those, more than three million are thought to have one of the four strains known to cause cases of cervical cancer and genital warts. ...> Full Article

Novel HIV Vaccine Funded for Clinical Development (9/2/2007)

A promising new HIV vaccine created at The Wistar Institute has received funding for clinical development aimed at moving the vaccine into human clinical trials as soon as possible. ...> Full Article

HPV Vaccine Does Not Appear To Be Effective For Treating Pre-Existing HPV Infection (8/17/2007)

For women with human papillomavirus (HPV) infection, use of the HPV-16/18 vaccine will not accelerate reduction of the virus and should not be used to treat the infection, according to a study in the August 15 issue of JAMA. ...> Full Article

Study Investigating Vaccine to Treat Brain Tumors Underway (8/5/2007)

Researchers at the University of Pennsylvania School of Medicine and the Abramson Cancer Center have begun ACT III – a Phase II/III Randomized Study – to investigate the addition of CDX-110 vaccine to standard care maintenance chemotherapy in patients with newly diagnosed glioblastoma multiforme (GBM), the most aggressive form of primary brain tumor. ...> Full Article

Trials Begin For 'Essential' New TB Vaccine (8/2/2007)

Clinical trials are underway with the first new vaccine against TB in over 80 years. If successful, the tests will have major implications for TB control and could lead to the development of a new vaccine ready to use within eight years. ...> Full Article

Universal Flu Vaccine Being Tested On Humans (7/21/2007)

A universal influenza vaccine that has been pioneered by researchers from VIB and Ghent University (Belgium) is being tested for the first time on humans by the British-American biotech company Acambis. This vaccine is intended to provide protection against all 'A' strains of the virus that causes human influenza, including pandemic strains. ...> Full Article

Biodesign Institute Leads Innovative Project to Prevent Breast Cancer (7/14/2007)

$7.5 million Department of Defense award ramps up ASU, Mayo Clinic collaboration to develop cancer vaccine ...> Full Article

Genetics Research Advances Possibility Of HIV Vaccine (7/10/2007)

A pioneering collaborative study has discovered how the HIV virus evades the human body's immune system. The research collaborative - involving scientists from the British Columbia Centre for Excellence in HIV/AIDS, Massachusetts General Hospital (MGH), Microsoft Research and Los Alamos National Laboratory - used highly computer-intensive, cutting-edge statistical research methods to investigate how the HIV virus mutates to escape the body's immune system. ...> Full Article

Subset Of Dendritic Cells Could Be Used To Fight Infection (7/7/2007)

Although few people in the United States have reason to have heard of it, leishmaniasis is a parasitic disease that occurs in 88 different tropical and subtropical countries. Yet despite its prevalence, there is currently no vaccine to prevent transmission. Now, research by Rockefeller University scientists brings an effective vaccine one step closer, showing how it should be possible to recruit a specific subset of immune cells to do the lion's share of the work. ...> Full Article

Rethinking Therapeutic Cancer Vaccine Trials (7/7/2007)

Ongoing therapeutic cancer vaccine trials have yet to show evidence of vaccines spurring a patient's immune system to shrink tumors -- yet patients who receive these vaccines in trials tend to live longer and respond better to subsequent treatment. In the July 1 issue of Clinical Cancer Research, a journal of the American Association for Cancer Research, a team of National Cancer Institute researchers asks a fundamental question: are we looking at cancer vaccine trials the wrong way? ...> Full Article

Team Unlocks Key To Safer Vaccines (6/22/2007)

A team from the University of Louisville has found clues that explain how one vaccine additive works to produce faster, stronger and longer lasting immunity than the vaccine alone. ...> Full Article

Researchers Conduct Innovative Smallpox Vaccine Research Study (6/3/2007)

University Hospitals Case Medical Center (UHCMC) and Case Western Reserve University School of Medicine are part of a nationwide research study to determine the safety and effectiveness of a new smallpox vaccine geared toward adults ages 18 to 34 who have never been vaccinated against the disease. The study is the first of its type in Northeast Ohio. ...> Full Article

International Studies Show HPV Vaccine is Highly Effective (6/2/2007)

A new vaccine aimed at preventing cervical cancer is nearly 100 percent effective against the two types of the human papillomavirus (HPV) responsible for most cases of cervical cancer--strains 16 and 18. Results of an international meta-analysis study of the vaccine are published in the June 1 issue of the journal Lancet. ...> Full Article

Researchers Develop Tuberculosis Vaccine (5/31/2007)

A Colorado State University research team has developed a novel vaccine to prevent tuberculosis, one of the world's most deadly diseases. The vaccine triggers the body's immunity in a novel way by activating specific immune system functions that enhance the response to the bacterium that causes tuberculosis. ...> Full Article

Oral Vaccine Containing Salmonella May Protect Against Aerosolized Anthrax (4/28/2007)

Researchers from the U.S. and abroad have developed an orally administered Salmonella-based vaccine that protects mice against aerosolized anthrax and may also have human implications. ...> Full Article

High Levels of Antibodies May Cause Low Levels of Cancer (4/20/2007)

Active immunisation can stimulate the body to produce highly efficient IgE antibodies that attack tumours. This breakthrough, achieved in an animal model, is based on the skilful combination of two established experimental methods. The results are now being published in Cancer Research and are part of a project funded by the Austrian Science Fund FWF. The antibodies produced during the project belong to a class that also plays a key role in the development of allergic reactions. Consequently, the results will be a key focal point at the 1st International AllergoOncology Symposium, which is to be held today in Vienna, Austria. ...> Full Article

Nation’s First Vaccine Against Bird Flu Approved (4/19/2007)

The U.S. Food and Drug Administration today announced the approval of the first vaccine in the nation’s history designed to prevent bird flu. ...> Full Article

New Cancer Vaccines Work by Stimulating the Immune System (4/19/2007)

As the first FDA-approved cancer vaccine, designed to protect against human papillomavirus, has moved from scientific discussion to social debate, other vaccine studies are continuing to make progress. While HPV vaccine efforts had the "benefit" of a viral source for the disease, other researchers are developing vaccines for cancers that are not virally based, in an effort to coax the immune system into attacking cancerous cells. Today at the 2007 Annual Meeting of the American Association for Cancer Research, presentations on ongoing HPV trials and other new approaches to stimulating the immune system are injecting momentum into cancer vaccine research. ...> Full Article

Novel Antigen-Cloning Technique May Boost Efforts to Develop a Melanoma Vaccine (4/18/2007)

In recent years, researchers have worked to develop a number of vaccines to help the immune system fight tumors. Cancer vaccines are not intended to prevent cancer; rather, they are used to boost immune responses to preexisting tumors. Unlike traditional chemotherapy, vaccines have relatively low toxicity and, potentially, a high degree of efficacy. ...> Full Article

Flu Vaccine Grown in Insect Cells (4/14/2007)

An experimental flu vaccine made in insect cells – not in eggs, where flu vaccines currently available in the United States are grown – is safe and as effective as conventional vaccines in protecting people against the flu, according to results published in the April 11 issue of the Journal of the American Medical Association. ...> Full Article