All Articles Tagged As: insulin

Is inhaled insulin delivery still a possibility? Why has it been a commercial failure? (9/26/2009)

The commercial failure of Exubera, the first inhaled insulin product to come to market, led other companies such as Eli Lilly-Alkermes to halt studies of similar drug delivery in development intended to compete for a share of the lucrative diabetes market. Does this signal defeat for efforts to deliver insulin via the lungs? ...> Full Article

Genes controlling insulin can alter timing of biological clock (9/22/2009)

Many of the genes that regulate insulin also alter the timing of the circadian clock, a new study has found. Although insulin responses were known to follow daily rhythms, the finding that components of the insulin-control system can reset the body's clock surprised the study's authors and suggests new approaches to treating disorders such as metabolic syndrome that can result, at least in part, from chronic disruption of the sleep-wake cycle. ...> Full Article

Diabetes advance: Researchers find gene that causes resistance to insulin (9/9/2009)

Discovery is first gene known to affect how insulin works, not how it is produced ...> Full Article

More insulin-producing cells, at the flip of a 'switch' (8/9/2009)

Researchers have found a way in mice to convert another type of pancreas cell into the critical insulin-producing beta cells that are lost in those with type I diabetes. The secret ingredient is a single transcription factor, according to the report in the Aug. 7 issue of Cell, a Cell Press journal. ...> Full Article

Scientists link elevated insulin to increased breast cancer risk (7/13/2009)

Elevated insulin levels in the blood appear to raise the risk of breast cancer in post-menopausal women, according to researchers at Albert Einstein College of Medicine of Yeshiva University. ...> Full Article

Findings show insulin - not genes - linked to obesity (4/17/2009)

Researchers have uncovered new evidence suggesting factors other than genes could cause obesity, finding that genetically identical cells store widely differing amounts of fat depending on subtle variations in how cells process insulin. ...> Full Article

Long-acting insulin analogues in type 2 diabetes: advantage over human insulin not proven (4/5/2009)

It has not been proven that long-acting insulin analogues have an advantage over human insulin in patients with type 2 diabetes. In its final report IQWiG concludes that even though one of two long-acting insulin analogues investigated has been on the market for 9 years, its benefits and harms have still not been investigated sufficiently. ...> Full Article

Stem cells crucial to diabetes cure in mice (3/19/2009)

More than five years ago, Dr. Lawrence C.B. Chan and colleagues in his Baylor College of Medicine laboratory cured mice with type 1 diabetes by using a gene to induce liver cells to make insulin."Now we know how it works," said Chan, director of the federally designed Diabetes and Endocrinology Research Center at BCM and chief of the division of endocrinology in BCM's department of medicine. "The answer is adult stem cells." ...> Full Article

Missing link between fructose, insulin resistance found (3/6/2009)

A new study in mice sheds light on the insulin resistance that can come from diets loaded with high-fructose corn syrup, a sweetener found in most sodas and many other processed foods. The report in the March issue of Cell Metabolism, a Cell Press publication, also suggests a way to prevent those ill effects. ...> Full Article

Compounds that trigger beta cell replication identified (3/2/2009)

Researchers at the Genomics Institute of the Novartis Research Foundation have identified a set of compounds that can trigger the proliferation of insulin-producing cells in the pancreas, using sophisticated high-throughput screening techniques. ...> Full Article

Vitamin K linked to insulin resistance in older men (11/29/2008)

A Tufts University study of 355 non-diabetic elderly men and women found men who took a vitamin K supplement had less progression of insulin resistance over a period of three years compared to men not receiving vitamin K. Vitamin K did not appear to protect supplemented women from age-related increases in insulin resistance. ...> Full Article

Killing 'angry' immune cells in fat could fight diabetes (10/10/2008)

By killing off 'angry' immune cells that take up residence in obese fat and muscle tissue, researchers have shown that they can rapidly reverse insulin resistance in obese mice. ...> Full Article

Scientists turn human skin cells into insulin-producing cells (9/21/2008)

Researchers have transformed cells from human skin into cells that produce insulin, the hormone used to treat diabetes. ...> Full Article

Battling Diabetes with Beta Cells (9/5/2008)

Team replicates insulin-producing cells, providing new hope for diabetics ...> Full Article

Researchers Create Insulin-Producing Cells from Adult Pancreatic Cells (8/31/2008)

Researchers have converted adult pancreatic cells into insulin-producing beta cells in living mice ...> Full Article

Treatment corrects severe insulin imbalance in animal studies (8/3/2008)

Could become first effective drug for rare genetic disorder in children ...> Full Article

Sourdough Bread Has Most Health Benefits, Prof Finds (7/13/2008)

Not all bread is created equal. The type of toast you eat for breakfast can affect how your body responds to lunch ...> Full Article

Finding a Single Mechanism for Hypertension, Insulin Resistance, and Immune Suppression (7/2/2008)

Researchers describe how they successfully reversed the SHR animals' symptoms of high blood pressure, a pre-diabetes condition called insulin resistance, and immune suppression ...> Full Article

Lifestyle can alter gene activity, lead to insulin resistance (6/23/2008)

A Finnish study of identical twins has found that physical inactivity and acquired obesity can impair expression of the genes which help the cells produce energy. The findings suggest that lifestyle, more than heredity, contributes to insulin resistance in people who are obese. Insulin resistance increases the chance of developing diabetes and heart disease. ...> Full Article

Genetic breakthrough explains dangerously high blood glucose levels (5/4/2008)

Discovery brings promise of "personalized medicine" closer to reality ...> Full Article

Insulin Pill Possibilities Starting to Gel; Engineer Reports Significant Progress (4/29/2008)

Insulin pills to replace the injections necessary for those suffering from diabetes appear closer to reality ...> Full Article

Researchers discover new effect for insulin (3/23/2008)

Plays previously unknown role in aging and lifespan ...> Full Article

Researchers uncover molecular connection between excessive nutrient levels and insulin resistance (2/22/2008)

For quite some time now, scientists suspected the so-called hexosamine pathway - a small side business of the main sugar processing enterprise inside a cell - to be involved in the development of insulin resistance. But they could never quite put their finger on the underlying mechanism. ...> Full Article

The missing link (2/20/2008)

Researchers home in on the connection between obesity and insulin resistance ...> Full Article