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All Articles Tagged As: genesHuman aging gene found in flies (5/12/2008)Scientists have found a fast and effective way to investigate important aspects of human aging ...> Full Article Bread mold may hold secret to eliminating disease-causing genes (5/10/2008)Scientist found mechanism that 'silences' unmatched genes during cellular reproduction ...> Full Article New Cancer Gene Discovered (5/10/2008)Researchers reduce protein; stop cancer growth – Plan to develop new cancer therapy target ...> Full Article Switching on cancer killer gene (5/9/2008)Scientists have discovered how to control a major anti-tumour gene that could lead to more effective chemotherapy ...> Full Article Gene sequence that can make half of us fatter is discovered (5/5/2008)A gene sequence linked to an expanding waist line, weight gain and a tendency to develop type 2 diabetes has been discovered ...> Full Article New discovery linked to DNA repair and cancer (5/4/2008)Scientists have discovered a new protein in humans that plays an important role in repairing DNA damage that could lead to cancer ...> Full Article The Genetic Background of Heart Failure and the Role of Hypertension (5/3/2008)Researchers have identified variations in a gene, which contributes to heart failure in the presence of hypertension. ...> Full Article Researchers identify new cell targets for preventing growth of breast and other tumors (4/26/2008)Researchers have discovered new targets for cancer treatment aimed at blocking a key step in tumor progression. ...> Full Article Mutation in human gene helps prevent malaria fatalities (4/25/2008)Researchers found that a deficiency in an enzyme provides protection against malaria infection. ...> Full Article Standard chemo works better against metastatic BRCA1/2 breast cancer than against sporadic tumors (4/25/2008)he first study to investigate the effects of chemotherapy on metastatic breast cancer in women with the BRCA1 or BRCA2 gene mutation has shown that standard chemotherapy works better in these patients than in women without the BRCA1/2 mutation. ...> Full Article Different mutations in a single gene suggests Parkinson's disease is primarily an inherited genetic disorder (4/21/2008)Two new international studies are rounding out the notion that Parkinson's disease is largely caused by inherited genetic mutations that pass through scores of related generations over hundreds, if not thousands of years ...> Full Article Researchers discover a method for clamping down on a cancer-promoting enzyme (4/20/2008)Researchers have now identified a molecule capable of shutting down cancerous gene before the enzyme becomes active ...> Full Article Inherited Cancer Mutation Is Widespread In America (4/20/2008)A gene mutation responsible for the most common form of inherited colon cancer is older and more common than formerly believed ...> Full Article Researchers Link 11 Genetic Variations to Type 2 Diabetes (4/4/2008)Mathematicians have developed powerful new tools for winnowing out the genes behind some of humanity's most intractable diseases. ...> Full Article Potential association of type 2 diabetes genes with prostate cancer (4/3/2008)Scientists have identified six new genes which play a role in the development of type 2 diabetes, and among the group is the second gene known to also play a role in prostate cancer ...> Full Article Gene and activity level of HDL-associated protein linked to risk of heart disease (3/21/2008)The gene for the HDL-associated protein paraoxonase 1 (PON1) appears to be associated with coronary artery disease ...> Full Article Gene Hunters Fine-Tune Marker for Common Obesity Gene (3/17/2008)In Children's DNA, a Hint of a Mutation's Ancestral African Origin ...> Full Article Researchers identify colorectal cancer gene (3/11/2008)Study is a step towards the future of genetic testing for the third most commonly diagnosed cancer in Americans ...> Full Article Scientists Hone Method To Selectively Target Cancer Genes and Cells (2/23/2008)A Genetic Cancer Genome Project is envisioned to identify new targets for cancer treatments ...> Full Article Genetic Mutation Found in Peripheral Artery Disease (2/23/2008)A tiny handful of genes appears to hold important clues to understanding why some patients with peripheral artery disease (PAD) face high rates of amputation and early death while others are spared those consequences, say researchers at Duke University Medical Center. ...> Full Article Gene Found to Play a Suppressor Role in Skin Cancer Development (2/9/2008)Researchers have provided genetic evidence that gene plays a suppressor role in skin cancer development. ...> Full Article New Insights Into Vaccination For HIV (2/3/2008)A group of Australian researchers at the Universities of Melbourne and New South Wales have developed new tools and paradigms to understand immune evasion from HIV. The study shows that both prior vaccination and timing influence the rates of immune escape, providing further insight into the effectiveness of T cell immunity to HIV. ...> Full Article BRCA1 mutation linked to breast cancer stem cells (2/3/2008)
Gene Predicts Heart Attack Response and Cardiac Damage (2/2/2008)A protein has been found that influences the response of the heart to a lack of oxygen and blood flow, such as occurs during a heart attack, a team of Yale School of Medicine researchers report today in Nature. ...> Full Article Genes Linked To Parkinson's Protection Identified (1/28/2008)Researchers have identified five genes within animal models displaying protective capabilities against a hallmark trait of Parkinson's disease. ...> Full Article Ebola virus disarmed by excising a single gene (1/23/2008)
At long last, culprit gene is found (1/19/2008)
Diet and lifestyle critical to recovery, says study (1/19/2008)Diet and lifestyle may play a much more significant role in a person's ability to respond favourably to certain drugs, including some cancer therapies, than previously understood, say scientists. ...> Full Article Researchers define eye cancer gene's role in retinal development (1/19/2008)Study provides the foundation for improving understanding of N-myc gene's role in the eyes' growth during fetal development when retinoblastoma forms ...> Full Article Scientists associate six new genetic variants with heart disease risk factor (1/17/2008)Genome-wide study finds a total of 18 DNA variants associated with levels of cholesterol and triglycerides in the blood ...> Full Article 10-Fold Life Span Extension Reported (1/15/2008)
Findings Point to Molecular 'Achilles Heel' for Half of Breast Cancer Tumors (1/15/2008)Researchers show why agents now being tested provide new treatment strategy ...> Full Article Small RNAs Can Prevent Spread of Breast Cancer (1/12/2008)Researchers have identified small pieces of ribonucleic acid (RNA) that suppress the spread of breast cancer to the lungs and bone. The new research shows that the most invasive and aggressive human breast cancer tumors are missing three critical microRNA molecules. When the researchers put those molecules back into human breast cancer tumors in mice, the tumors lost their ability to spread. ...> Full Article Genetic breakthrough offers promise in tackling kidney tumours (1/12/2008)A new study has shown promising results in fighting a severe genetic disorder which can create tumours throughout the body. ...> Full Article Breast Cancer Risk Varies Significantly Among Brca1 And Brca2 Carriers (1/11/2008)There is a broad variation in the risk of developing breast cancer among people who carry the BRCA1 and BRCA2 gene mutation, according to a study in the January 9/16 issue of JAMA. ...> Full Article RNA Shown To Silence Cancer Suppressor Gene (1/10/2008)Discovery sheds light on 'epigenetic' mechanisms in tumor development in plants and animals ...> Full Article International team identifies 480 genes that control human cell division (1/9/2008)A team of U.S., Israeli and German scientists used computational biology techniques to discover 480 genes that play a role in human cell division and to identify more than 100 of those genes that have an abnormal pattern of activation in cancer cells. ...> Full Article New Biomarker Predicts Liver Cancer Spread and Survival (1/8/2008)New research has shown that a unique pattern of microRNAs, small RNA molecules that regulate gene activity, can accurately predict whether liver cancer will spread and whether liver cancer patients will have shorter or longer survival, even patients with early stage disease. The study, which appeared online January 7, 2008 in Hepatology, was conducted by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and colleagues at Ohio State University, Columbus, and the Liver Cancer Institute in Shanghai, China. ...> Full Article New Gene Identified for Condition that Causes Blood Clots in Brain (1/8/2008)Researchers have identified a new gene linked to cerebral venous thrombosis, a condition that causes blood clots in the veins of the brain that can lead to stroke. The condition is more common in young and middle-aged women. The research is published in the January 8, 2008, issue of Neurology®, the medical journal of the American Academy of Neurology. ...> Full Article Gene Dose Affects Tumor Growth (1/7/2008)Researchers at Johns Hopkins and Ohio State University have found that the number of copies of a particular gene can affect the severity of colon cancer in a mouse model. Publishing in the Jan. 3 issue of Nature, the research team describes how trisomy 21, or Down syndrome in humans, can repress tumor growth. ...> Full Article Gene Protects Newborns from Killer Respiratory Disease (1/5/2008)Yale School of Medicine researchers have isolated a gene that helps protect newborns from the most common respiratory cause of infant death in the United States-respiratory distress syndrome. ...> Full Article More Teen Women Battling Heart Disease (1/5/2008)At the age of 18, most young women are embarking on adulthood without a care in the world-health included. ...> Full Article Lung Cancer Cells' Survival Gene Seen as Drug Target (1/4/2008)One of the deadliest forms of cancer appears to carry a specific weakness. When a key gene called 14-3-3zeta is silenced, lung cancer cells can't survive on their own, researchers have found. ...> Full Article Study examines genetic defects linked to body abnormalities in patients with childhood cancer (1/4/2008)Children with cancer have a higher prevalence of body abnormalities, such as asymmetric lower limbs and curvature of the spine, suggesting that the genetic defect responsible for the abnormality may play a role in the development of cancer, according to a study in the January 2 issue of JAMA. ...> Full Article Gene variation may elevate risk of liver tumor in patients with cirrhosis (1/3/2008)Growth factor pathway may be target for preventive treatment ...> Full Article Overeating And Obesity Triggered By Lack Of One Gene (1/1/2008)According to the Centers for Disease Control and Prevention, close to one-third of the population in the United States is obese and another third is overweight. Excessive weight gain is elicited by alterations in energy balance, the finely modulated equilibrium between caloric intake and expenditure. But what are the factors that determine how much food is consumed? ...> Full Article Two Genes Are Important Key to Regulating Immune Response (12/31/2007)Pbx-1, Prep-1 Help Spur IL-10 Production; Findings Have Implications for Research into Lupus, Cancer and HIV/AIDS ...> Full Article Breast cancer gene mutation more common in Hispanic, young black women (12/28/2007)A genetic mutation already known to be more common in Ashkenazi Jewish breast cancer patients is also prevalent in Hispanic and young African-American women with breast cancer, according to one of the largest, multiracial studies of the mutation to date. ...> Full Article Heart Attack Risk From Smoking Due to Genetics (12/22/2007)Heart attacks among cigarette smokers may have less to do with tobacco than genetics. ...> Full Article Firefly genes allow testing of new therapy against lymphoma (12/20/2007)Researchers here have figured out a way to use a firefly gene to let them see just how effective a new drug combination actually is against some forms of cancer and its serious complication. ...> Full Article Mutant Gene Identified as Villain in Hardening of the Arteries (12/20/2007)A genetic mutation expands lesions in the aorta and promotes coronary atherosclerosis, more commonly known as hardening of the arteries, according to a study by Yale School of Medicine in Cell Metabolism. ...> Full Article Molecular 'trip switch' shuts down inflammatory response (12/19/2007)Like a circuit breaker that prevents electrical wiring from overheating and bringing down the house, a tiny family of three molecules stops the immune system from mounting an out-of-control, destructive inflammatory response against invading pathogens, researchers at the Salk Institute for Biological Studies have found. ...> Full Article Researchers Discover Virus Using Same Tools as Host Cell (12/17/2007)Duke University Medical Center researchers have discovered that the virus which causes Kaposi's Sarcoma encodes a molecule for controlling gene regulation nearly identical to one found normally in human cells. Both versions of the molecule, known as a microRNA, appear to play a role in the development of cancer. ...> Full Article Most carriers of Fanconi anemia genes are not at a higher risk of cancer (12/15/2007)For almost 50 years, Fanconi anemia has been associated with leukemia. Not just among those who have the genetic disorder but among their family members, whose genes, they were told, made them highly susceptible to a variety of malignancies. But a new study to examine links between 13 specific Fanconi anemia genes and cancer risk has determined that in most cases, their risk of cancer is no greater than that of the rest of the population. ...> Full Article Hormone Fuels Certain Cancer Mutation (12/15/2007)A researcher has discovered that a particular hormone is responsible for driving a cancer enzyme to cause an often deadly red blood cell cancer. ...> Full Article New study reveals for first time how BRCA1 mutations cause breast cancer (12/14/2007)Finding Implicates Tumor Suppressor Gene, PTEN Columbia University Medical Center among Two Institutions to Identify this Gene in 1997 ...> Full Article Silencing small but mighty cancer inhibitors (12/13/2007)Researchers from Johns Hopkins and the University of Pennsylvania have uncovered another reason why one of the most commonly activated proteins in cancer is in fact so dangerous. As reported in Nature Genetics this week, the Myc protein can stop the production of at least 13 microRNAs, small pieces of nucleic acid that help control which genes are turned on and off. ...> Full Article Keeping at-risk cells from developing cancer (12/12/2007)Researchers at Johns Hopkins have discovered that cancers arising from epigenetic changes - in this case the inappropriate activation of a normally silent gene - develop by becoming addicted to certain growth factors. Reporting online in next week's Early Edition of the Proceedings of the National Academies of Sciences, the team shows that blocking this "addiction" can greatly prevent cancer growth. ...> Full Article Study Finds Gene Linked to Aggressive Prostate Cancer (12/12/2007)Results from two genome-wide association studies have identified a genetic variant of the DAB2IP gene that is associated with the risk of aggressive prostate cancer. Research teams from the Translational Genomics Research Institute (TGen), Wake Forest University School of Medicine, the Karolinska Institute in Stockholm, Sweden, and Johns Hopkins Medical Institutions made the discovery jointly. ...> Full Article The mouse that roared (12/7/2007)How do complex networks of genes control obesity, cancer and heart disease? The unique rodents of the Oklahoma Medical Research Foundation may hold the answer. ...> Full Article New marker identifies cancer stem cells (12/7/2007)Marker corresponds to worse outcomes, could help determine treatments ...> Full Article Gene variant behind diabetes confirmed (12/6/2007)Certain forms of the WFS1 gene that influence the risk of type 2 diabetes - also called adult-onset diabetes- have been confirmed for the first time by an international team of scientists led by Umeå University researcher Paul W. Franks. The findings have been published in the high-ranking diabetes journal, Diabetologia. ...> Full Article Waistline growth on high-carb diets linked to liver gene (12/5/2007)
Could hydrogen sulfide hold the key to a long life? (12/4/2007)Study finds 'rotten egg' chemical increases life span and heat tolerance in worms ...> Full Article Genes identified that protect against heart damage from chemotherapy (12/4/2007)A series of genes that protect cells from the powerful, common chemotherapeutic agent doxorubicin has been identified by researchers working to understand how the drug also can destroy the heart. ...> Full Article DNA Methylation Shown To Promote Development Of Colon Tumors (12/2/2007)Damaged or defective genes have long been known to be the cause of some cancers. Over the past decade, however, scientists have discovered that even healthy genes can be switched on or off and can cause cancer without any changes in the underlying DNA sequence--although how this happens has remained poorly understood. ...> Full Article Scientists See Breast Cancer Gene Activity from Outside the Body (11/30/2007)Jefferson Scientists See Breast Cancer Gene Activity from Outside the Body ...> Full Article Researchers identify key genetic trigger of acute myeloid leukemia (11/29/2007)A gene called N-Myc leads a double life in certain white blood cells when it is overexpressed, helping to trigger a cancer called acute myeloid leukemia (AML) under some conditions while triggering apoptosis, or cell suicide, under other conditions, according to results of a mouse study done by investigators at St. Jude Children's Research Hospital. ...> Full Article Cancer-resistant Mouse Developed By Adding Tumor-suppressor Gene (11/29/2007)A mouse resistant to cancer, even highly-aggressive types, has been created by researchers at the University of Kentucky. The breakthrough stems from a discovery by UK College of Medicine professor of radiation medicine Vivek Rangnekar and a team of researchers who found a tumor-suppressor gene called "Par-4" in the prostate. ...> Full Article Too Much Sugar Turns Off Gene That Controls Effects Of Sex Steroids (11/26/2007)Eating too much fructose and glucose can turn off the gene that regulates the levels of active testosterone and estrogen in the body, shows a new study in mice and human cell cultures that's published this month in the Journal of Clinical Investigation. This discovery reinforces public health advice to eat complex carbohydrates and avoid sugar. Table sugar is made of glucose and fructose, while fructose is also commonly used in sweetened beverages, syrups, and low-fat food products. Estimates suggest North Americans consume 33 kg of refined sugar and an additional 20 kg of high fructose corn syrup per person per year. ...> Full Article Researchers Find Monkeys Able to Fend Off AIDS-like Symptoms with Enhanced HIV Vaccine (11/22/2007)Researchers have discovered that using an immune system gene to enhance a vaccine used to study HIV in macaque monkeys provides the animals with greater protection against simian HIV (SHIV) than an unmodified vaccine. This multi-year study found that the addition of a molecule called Interleukin-15 effectively boosts the effects of a vaccine derived from the DNA of simian HIV. The study illustrates that DNA vaccine effectiveness can be improved by the inclusion of specific immune adjuvants, or helpers. ...> Full Article Identification of a gene that regulates thyroid hormones (11/22/2007)Researchers at IRB Barcelona report the first data on the functions of a new gene that is altered in diabetes ...> Full Article Cancer drug works by stimulating cancer gene (11/21/2007)
Grape powder blocks genes linked to colon cancer (11/19/2007)Study points to potential for dietary prevention of third most common form of cancer ...> Full Article Researchers Identify Tumor-Suppressor Gene for Lung Cancer (11/18/2007)The GPRC5A gene, which is under-expressed in human lung cancer cells, suppresses lung tumors in mouse models and could provide a key to attacking lung cancer in humans, researchers at The University of Texas M. D. Anderson Cancer Center report in the Nov. 21 edition of The Journal of the National Cancer Institute. ...> Full Article Cancer Cell Genes Can be Switched Off (11/17/2007)Study shows epigenetic silencing involves distinct changes in DNA structure. ...> Full Article Scorpion Toxin Makes Fungus Deadly to Insect Pests (11/17/2007)Professor has discovered how to use scorpion genes to create a hypervirulent fungus that can kill specific insect pests, including mosquitoes that carry malaria and a beetle that destroys coffee crops, but does not contaminate the environment as chemical pesticides do. ...> Full Article New insight into the link between genetics and obesity (11/15/2007)Scientists have acquired new insight into how the 'obesity gene' triggers weight gain in some individuals. ...> Full Article Gene discovery opens new avenue for treatments (11/8/2007)The discovery of how a particular gene in the human body suppresses autoimmune diseases like Type 1 diabetes and lupus could open the way for a completely new approach to treating such conditions, scientists propose. ...> Full Article Team Uncovers Gene's Role in Type 1 Diabetes (11/7/2007)Researchers at the University of Virginia Health System have identified an enzyme thought to be an important instigator of the inner-body conflict causes Type 1 diabetes. A chronic condition that affects nearly 3 million American children and adults, Type 1 diabetes is more severe than Type 2. Type 1 diabetes, also called autoimmune diabetes, arises when the body's infection-fighting white blood cells start destroying the beta-cells that produce insulin in the pancreas. ...> Full Article Researchers identify gene behind rheumatoid arthritis (11/7/2007)Researchers have identified a genetic variant in a region on chromosome 6 that is associated with rheumatoid arthritis (RA), the most common inflammatory arthritis affecting 387,000 people in the UK. ...> Full Article Biomarker May Be an Early Predictor of Advanced Breast Cancer (11/7/2007)Researchers have identified a molecule that may be more accurate than existing biological signposts used to predict which breast cancers will develop into advanced forms of the disease. ...> Full Article How One Virus Uses Mimicry To Replicate Successfully: Related Mechanisms May Trigger Some Cancers (11/6/2007)Both viruses and cancers subvert the growth-control machinery in a cell to serve their own needs. According to a new study, at least one virus uses mimicry to gain access to that machinery. ...> Full Article Tumor genome analysis unveils new insights into lung cancer (11/6/2007)An international consortium of scientists today in an advanced online publication in the journal Nature revealed a comprehensive view of the altered genetic background of the type of lung cancer that is the most common cause of cancer deaths in humans. ...> Full Article SUMO wrestles SENP1 over response to hypoxia, providing possible cancer targets (11/5/2007)Researchers have found a protein that enables cellular survival during periods of low oxygen, or hypoxia, which also is key for development of many kinds of cancer. ...> Full Article Cardiologists Identify New Gene Responsible for Sudden Cardiac Arrest (11/5/2007)Researchers at the University of Pittsburgh School of Medicine have identified a new gene responsible for a rare, inherited form of sudden cardiac arrest, known as Brugada syndrome. With the identification of this new gene, the researchers hope this will shed light on the more common forms of sudden death in patients with heart attacks and heart failure, and will help aid in the development of new, effective therapeutic treatments that will prevent all types of fatal arrhythmias. ...> Full Article New Genetic Variant Linked To Prostate Cancer In African-Americans (11/4/2007)Researchers report a newly identified genetic variation that is linked to higher incidence of prostate cancer in African American men. Two tiny genetic variations may provide the best clues yet for finding more precise ways to estimate prostate cancer risk and improve screening and early detection for men of African descent. ...> Full Article New gene may offer clues to infertility in both cows and women (11/3/2007)A newly identified gene that controls embryo development in cows may someday offer clues into the cause of infertility in women. ...> Full Article Research Links Genetic Mutations to Lupus (10/30/2007)A gene discovery has been linked to lupus and related autoimmune diseases. The finding is the latest in a series of revelations that shed new light on what goes wrong in human cells to cause the diseases. ...> Full Article Possible Biomarker For Colon Cancer In People 50 And Under Identified (10/29/2007)An abnormality of chromosomes long associated with diseases of aging has, for the first time, been linked to colon cancer in people 50 years old and younger, an age group usually considered young for this disease. ...> Full Article Researchers find obesity genes hidden in discarded data (10/25/2007)Previously hidden obesity-related genes have been uncovered from old experiments by researchers at the Stanford University School of Medicine and Lucile Packard Children's Hospital. The finding suggests that useful information about many medical disorders may be languishing in mountains of discarded data. ...> Full Article Eating To Live, Living To Eat: Genes May Make Some People More Motivated To Eat, Perhaps Overeat (10/23/2007)Obesity researchers find clues to individual risk factors; gene studies could lead to better, tailored treatment ...> Full Article New fatal genetic heart disease discovered (10/23/2007)Researchers have discovered a previously unknown congenital disease that is caused by a genetic defect resulting in muscle cells not being able to store energy from sugar. In the worst case, the disease can lead to the heart stopping. ...> Full Article Immune cells fighting chronic infections become progressively 'exhausted,' ineffective (10/21/2007)A new study of immune cells battling a chronic viral infection shows that the cells, called T cells, become exhausted by the fight in specific ways, undergoing profound changes that make them progressively less effective over time. ...> Full Article Scientists Identify New Gene Associated with Lung Cancer (10/19/2007)The first research to show the involvement of a gene known as Dmp1 in human lung cancer will hopefully lead to an increased understanding on what goes wrong at the cellular level to cause the disease. ...> Full Article Study identifies pathway required for normal reproductive development (10/19/2007)Gene defects cause infertility, lack of sense of smell in humans and mice ...> Full Article Genes That Both Extend Life And Protect Against Cancer Identified (10/18/2007)A person is 100 times more likely to get cancer at age 65 than at age 35. But new research reported today in the journal "Nature Genetics" identifies naturally occurring processes that allow many genes to both slow aging and protect against cancer in the much-studied C. elegans roundworm. ...> Full Article Enzyme's cancer-promoting activities linked to inactivation of 'genome guardian' (10/18/2007)The enzyme WIP1 becomes cancer-causing when there is too much of it, preventing the p53 gene from protecting the genome against dangerous DNA mutations. ...> Full Article Gene Believed To Promote Long Life Linked To Cholesterol Flushing (10/15/2007)Researchers have discovered a link between a gene believed to promote long lifespan and a pathway that flushes cholesterol from the body. ...> Full Article Genetic 'Roadblock' Hoped To Inspire Future Type 2 Diabetes Research (10/13/2007)A team of researchers has found that a 'genetic roadblock' identified in a recent study could pave the way toward novel treatments for type 2 diabetes. ...> Full Article Surveying the Genetic Landscape of Breast and Colon Cancers (10/13/2007)
'Network' approach yields discovery of a potential breast cancer susceptibility gene (10/13/2007)Like a crossword-puzzle solver who uses the letters in some answers to figure out others, researchers have used data on genes involved in inherited forms of breast cancer to identify a novel gene potentially linked to the disease. ...> Full Article Research links gene to cholesterol (10/12/2007)Research could lead to drugs for atherosclerosis, Alzheimer's ...> Full Article Scientists identify Genes that Affect Responses of Multiple Sclerosis Patients to Copaxone® (10/11/2007)A group of scientists have recently identified genes responsible for the positive response of many multiple sclerosis patients to the drug Copaxone®. These findings may contribute to the development of personalized medicine for multiple sclerosis sufferers. ...> Full Article Researchers find new gene linked to breast cancer (10/11/2007)Multicenter study suggests HMMR increases breast cancer risk ...> Full Article Gene may hold key to future cancer hope (10/10/2007)Scientists may have discovered a new way of killing tumours in what they hope could one day lead to alternative forms of cancer treatments. ...> Full Article Scientists find 'skinny' gene's value (10/9/2007)Scientists have learned the role of a key gene in the war on weight, a tiny bundle of DNA discovered in fruit flies 50 years ago. ...> Full Article Gene that lowers cell stress could protect against Parkinson's Disease (10/8/2007)The discovery of a relationship between two cell enzymes and their role in keeping the cell's energy generating machinery working smoothly could provide a new target for development of therapies for Parkinson's disease. ...> Full Article Gene Chip Data Improved Therapy in Some Patients with Incurable Cancer (9/21/2007)"Crude" personalized medicine holds promise even when it is still in its infancy as a technology ...> Full Article Liver Cancer Marker Could Yield Blood Test for Early Detection (9/20/2007)In the face of an emerging liver cancer crisis in Asia, researchers at the Chinese University of Hong Kong have developed a test that could help millions. Due to widespread hepatitis B virus (HBV) infection, nearly 10 percent of China's population is at high risk for hepatocellular carcinoma (HCC), a liver cancer with low survival rates if not detected and treated early. Researchers report on a new blood screening technique that could make it possible to detect early-stage liver cancer and predict how well a patient will do following treatment. ...> Full Article Test for Lung Cancer Looks for Discomforting Quiet among Protective Genes (9/20/2007)When it is quiet - "almost too quiet" - in movies, it is a sign that something is about to go wrong for the good guys. This holds true for the genes that protect against lung cancer, as researchers at the University of Toledo in Toledo, Ohio, have learned. They identified a panel of 15 genes that could serve to predict cancer; if enough of their collective activity becomes quiet - almost too quiet -- it could mean they are being suppressed by other factors in the cell, a step that may lead to cancer. ...> Full Article Genes and disease? It's what you do with what you have (9/18/2007)The importance of gene regulation for common human disease ...> Full Article Gene Abnormality Tied to Getting Parkinson's Disease at a Younger Age (9/18/2007)People with a certain gene mutation are more likely to get Parkinson's disease before the age of 50 compared to those without the gene abnormality, according to a study published in the September 18, 2007, issue of Neurology®, the medical journal of the American Academy of Neurology. ...> Full Article If You Think Cancer Genes Are Simple, You Don't Know JAK (9/18/2007)
NIH Awards Einstein Researcher Multi-Million Dollar Grant To Extend Our Understanding of Exceptional Longevity (9/18/2007)Albert Einstein College of Medicine of Yeshiva University has been awarded a grant of more than $9.25 million from the National Institutes of Health to further the medical school's study of centenarians and the biology of aging. ...> Full Article Unraveling interconnected paths to disease (9/18/2007)Under new NIH initiative, Broad Institute scientists partner with researchers nationwide to unveil genetic and environmental triggers of human disease ...> Full Article Seattle Children's Hospital Leads $23.7 Million NIH Grant to Study Gene Repair (9/9/2007)Seattle Children's Hospital will receive the largest research grant in its 100-year history for a new five-year, eleven-part grant awarded by the National Institutes of Health (NIH) to study gene repair. The $23.7 million grant will support the Northwest Genome Engineering Consortium, led by Andrew M. Scharenberg, MD, of Seattle Children's Hospital Research Institute in partnership with the University of Washington School of Medicine (UWSOM) and Fred Hutchinson Cancer Research Center. Approximately $13.2 million will be directly awarded to Children's, with $5.3 million going to UWSOM and $5.2 million to the Hutchinson Center. ...> Full Article Researchers find genetic link between body clocks and blood pressure (9/4/2007)
Discovery Suggests Location of Genes for Breast Density, a Strong Risk Factor for Breast Cancer (9/2/2007)Studying the DNA of 889 people, gene hunters at the Mayo Clinic and H. Lee Moffitt Cancer Centers have identified a region on chromosome 5p that is significantly associated with dense breast tissue, a known risk factor for breast cancer. The findings, published in the September 1 issue of Cancer Research, a publication of the American Association for Cancer Research, suggest that genes which influence breast density could serve as a predictive marker for disease and provide a biological target for agents that may reduce breast cancer risk by reducing breast density. ...> Full Article Small molecule spurs genes to action (8/22/2007)Most of us think of disease as the failure of an organ or the breach of some critical fortress in the body's defense system. But for many ailments, including cancer and diabetes, disease begins with an even more fundamental error: the failure of genes to turn on and off when they should. ...> Full Article Key to Out-of-Control Immune Response in Lung Injury Found (8/20/2007)Researchers at the University of Illinois at Chicago College of Medicine have discovered how a protein modulates the inflammatory response in sudden, life-threatening lung failure. The protein's previously unknown role is reported in the August issue of Nature Medicine. ...> Full Article Defects in critical gene lead to accelerated lung tumor growth (8/18/2007)Cancer causing mutations occur in our bodies every day - but luckily, we have specific genes that recognize these malignant events and keep cells from growing out of control. Only a few of these genes - called tumor suppressors - are currently known. ...> Full Article Reactivating a critical gene lost in kidney cancer reduces tumor growth (8/18/2007)Researchers at Mayo Clinic Jacksonville have found that a key gene is often "silenced" in clear cell renal cell carcinoma, the most common type of kidney cancer, and when they restored that gene in human kidney cancer cells in culture and animal experiments, tumors stopped growing and many disappeared. ...> Full Article First Biomarker Discovered that Predicts Prostate Cancer Outcome (8/17/2007)Mayo Clinic researchers have identified the first immune molecule that appears to play a role in prostate cancer development and in predicting cancer recurrence and progression after surgery. The report on the B7-H3 molecule by Mayo Clinic Cancer Center appears today in Cancer Research. ...> Full Article Researchers Find Diabetes Drug Kills Some Cancer Cells (8/14/2007)Researchers at the University of Pennsylvania School of Medicine have found that a commonly prescribed diabetes drug kills tumor cells that lack a key regulatory gene called p53. ...> Full Article Protein Plays Role in Increased Skin Pigmentation (8/14/2007)
Genetic Finding Sheds Light On Diseases Causing Blood Vessel Breakdown (8/10/2007)Twenty-one years after they first described a fatal genetic disorder in Missouri and Arkansas families, scientists at Washington University School of Medicine in St. Louis have linked the condition to mutations in a gene known as TREX1. ...> Full Article Multi-Center Study Nets New Lung Tumor-Suppressor Gene (8/8/2007)Collaborating scientists in Boston and North Carolina have found that a particular gene can block key steps of the lung cancer process in mice. The researchers report in the journal Nature that LKB1 is not only a "tumor-suppressor" gene for non-small cell lung cancer in mice, it also may be more powerful than other, better-known suppressors. ...> Full Article Molecule Blocks Gene, Sheds Light on Liver Cancer (8/6/2007)New research shows how a particular small molecule blocks the activity of a cancer-suppressing gene, allowing liver-cancer cells to grow and spread. ...> Full Article Flip Of Genetic Switch Causes Cancers In Mice To Self-Destruct (8/3/2007)Killing cancerous tumors isn't easy, as anyone who has suffered through chemotherapy can attest. But a new study in mice shows that switching off a single malfunctioning gene can halt the limitless division of tumor cells and turn them back to the path of their own planned obsolescence. ...> Full Article Researchers Identify Gene Involved In Breast Cancer (7/28/2007)Researchers at the University of Michigan Comprehensive Cancer Center have identified a gene linked to the development of an aggressive form of breast cancer. ...> Full Article Scientists Lift Lid On Genetics Of Coronary Artery Disease (7/23/2007)Scientists have moved a step closer to understanding how our genetic make-up can lead us to develop heart disease and to predicting who is most at risk. In a study published today, they have confirmed six new genetic variants that increase the likelihood of developing coronary artery disease. Heart disease is the UK's largest killer, accounting for 105,000 deaths annually. ...> Full Article Potential New Target for Cancer Found (7/22/2007)By bypassing a well-known gene implicated in almost one-third of all cancers and instead focusing on the protein activated by the gene, Duke University Medical Center researchers believe they may have found a new target for anti-cancer drugs. ...> Full Article Gene Discovered for Type 1 Diabetes in Children (7/21/2007)Pediatrics researchers at The Children's Hospital of Philadelphia and McGill University in Montreal have identified a gene variant that raises a child's risk for type 1 diabetes, formerly called juvenile diabetes. As investigators continue to pinpoint genes contributing to diabetes, they have their eyes on providing a scientific basis for designing better treatments and preventive measures for the disease. ...> Full Article A Gene That Protects From Kidney Disease (7/15/2007)A combination of mice and patient studies sheds light on cause and possible new therapies of kidney diseases ...> Full Article Gene's Activity Points to More Lethal Subtype of AML (7/14/2007)A new study shows that the activity of a particular gene can identify people who have a more lethal form of acute myeloid leukemia, singling out those patients who should receive more intense therapy. ...> Full Article WFS1 Gene In More Common In People With Type 2 Diabetes (7/6/2007)Researchers led by Cambridge scientists have defined a role for a gene called WFS1 in diabetes. Using their understanding of diabetes, they made educated choices about which genes might contribute. Their research, published in Nature Genetics today, hit gold with the revelation that a variant of WFS1 is more common in type 2 diabetes patients than in unaffected people ...> Full Article Possible Relation Between Dairy Consumption And Mutations Of A Gene That Causes Pancreatic Cancer Uab Barcelona (7/5/2007)
Sensitive Genetic Analysis Reveals Vast Changes Associated With Inherited Heart Disorder (6/15/2007)The one-gene, one-disease concept is elegant, but incomplete. A single gene mutation can cause many other genes to start-or stop-working, and it may be these changes that ultimately cause clinical symptoms. Identifying the complete set of affected genes used to appear impossible. Not anymore. ...> Full Article Largest Ever Study Of Genetics Of Common Diseases (6/12/2007)
Gene Recipe For Common Diseases (6/11/2007)
Researchers Reveal Clues To New Genes Behind Rheumatoid Arthritis (6/10/2007)Researchers at the University of Manchester have identified evidence of several new genes behind the chronic inflammatory disease rheumatoid arthritis (RA), which affects 387,000 people in the UK. ...> Full Article Gene Switched Off In Cancer Can Be Turned On (6/9/2007)Study lays groundwork for developing a new class of targeted therapies ...> Full Article Genetic Variations May Predispose Some Men To Suicidal Thoughts During Short-term Treatment For Depression (6/9/2007)Genetic variations may help explain why some men with depression develop suicidal thoughts and behaviors after they begin taking antidepressant medications, while most do not, according to a report in the June issue of Archives of General Psychiatry, one of the JAMA/Archives journals. ...> Full Article Largest Synthetic Gene Ever Built Offers Insights Into Anti-Malarial Drug Resistance (6/7/2007)Researchers at Georgetown University Medical Center say they are moving closer to understanding why the most lethal form of human malaria has become resistant to drug treatment in the past three decades. They have been able to artificially construct, and then express in yeast, a protozoan gene that contributes to such resistance. And it was no small feat. The gene they laboriously constructed over a two-year period is believed to be the largest 'synthetic' one ever built, and it successfully produces large quantities of the encoded protein, whose function can now be easily studied. ...> Full Article Researchers Discover Inherited Mutation For Leukemia (6/3/2007)Researchers have discovered the first inherited gene mutation that increases a person's risk for chronic lymphocytic leukemia (CLL), one of the most common forms of the disease. ...> Full Article Common Cancer Gene Sends Death Order To Tiny Killer (6/2/2007)Scientists at Johns Hopkins have discovered one way the p53 gene does what it's known for-stopping the colon cancer cells. Their report will be published in the June 8 issue of Molecular Cell. ...> Full Article World First Study Of Faulty Genes For Breast Cancer (6/1/2007)Results of a world-first, large-scale study of faulty genes and breast cancer, with significant Australian contributions including research from the University of Melbourne will be released in Nature today. ...> Full Article Mutant Parasites, Unable To Infect Hosts, Highlight Virulence Genes (5/31/2007)With a single approach, microbiologists at the University of Wisconsin-Madison have identified dozens of clues to how human parasites may infect their hosts. ...> Full Article Researchers Home In On Possible New Breast Cancer Gene (5/28/2007)
Tiny Genes May Increase Cancer Susceptibility (5/27/2007)New evidence indicates that small pieces of noncoding genetic material known as microRNAs (miRNAs) might influence cancer susceptibility. Differences in certain miRNAs may predispose some individuals to develop cancer, say researchers collaborating in a joint study at the Kimmel Cancer Center at Jefferson in Philadelphia, Ohio State University Medical Center in Columbus and Roswell Park Cancer Institute in Buffalo. ...> Full Article Study Identifying Alteration in Gene Associated with Uterine Cancer Lays Groundwork for More Targeted Therapies (5/25/2007)Collaboration led by TGen and Washington University School of Medicine may accelerate therapeutic development ...> Full Article New DNA Tests Advance Diagnosis/Early Treatment of Lysosomal Storage Diseases (5/23/2007)A new set of laboratory tests using gene sequencing is able to help confirm 24 lysosomal storage diseases, providing physicians and patients the tools for much more accurate and rapid diagnosis. Lysosomal storage diseases are a group of more than 40 inherited and potentially life-threatening disorders that cause enzymes to malfunction in cellular compartments called lysosomes. This leads to the accumulation of waste products that damage organs and tissues. ...> Full Article Team ID's Cell Mechanics Of Hallmark Malaria Protein (5/23/2007)During the first 24 hours of invasion by the malaria-inducing parasite Plasmodium falciparum, red blood cells start to lose their ability to deform and squeeze through tiny blood vessels--one of the hallmarks of the deadly disease that infects nearly 400 million people each year. Now, an international team of researchers led by an MIT professor has demonstrated just why that happens. ...> Full Article Genetic Marker Linked To Aggressive Prostate Cancer (5/22/2007)Northwestern University researchers have discovered that a recently identified genetic marker for prostate cancer is linked to a highly aggressive form of the disease. ...> Full Article Study To Investigate Gene's Effect On Bone Loss In Breast Cancer Patients (5/18/2007)Women with estrogen-responsive breast cancer are often prescribed a drug that reduces their estrogen levels. But because estrogen is important to bone health, there is widespread concern about how the estrogen-reducing drugs - called aromatase inhibitors - affect bones. ...> Full Article Gene Thought to Assist Chemo May Help Cancer Thrive (5/17/2007)
Team Unearths Genetic Risk Factors For Diabetes (5/16/2007)Three novel regions of the genome influence the risk of type 2 diabetes ...> Full Article Effect On Breast Tumors Of Dna Alternations In 3 Genes Described (5/16/2007)Cancer epidemiologists at the University at Buffalo have identified specific genes that are most likely to become cancer promoters when exposed to a process called DNA promoter hypermethylation. ...> Full Article Inherited Genes Linked To Toxicity Of Leukemia Therapy (5/15/2007)Investigators at St. Jude Children's Research Hospital have discovered inherited variations in certain genes that make children with acute lymphoblastic leukemia (ALL) susceptible to the toxic side effects caused by chemotherapy medications. The researchers showed that these variations, called polymorphisms, occur in specific genes known to influence pharmacodynamics (how drugs work in the body and how much drug is needed to have its intended effect). ...> Full Article Common Genetic Variation Is Linked To Substantial Risk In Heart Attack (5/7/2007)A common genetic variation on chromosome 9p21 is linked to a substantial increase in risk for heart attack, according to a new international research study. The findings are published in the online edition of Science, and will appear in an upcoming printed edition of the journal. ...> Full Article Inflammatory System Genes Linked To Cognitive Decline After Heart Surgery (5/7/2007)Variants of two genes involved in the inflammatory system appear to protect patients from suffering a decline in mental function following heart surgery. ...> Full Article Scientists Discover Rare Gene-For-Gene Interaction That Helps Bacteria Kill Their Host (5/7/2007)Scientists have discovered that a cousin of the plague bacterium uses a single gene to out-fox insect immune defences and kill its host. ...> Full Article Researchers Discover First Gene That Specifically Links Calorie Restriction To Longevity (5/3/2007)In studies going back to the 1930's, mice and many other species subsisting on a severely calorie-restricted diet have consistently outlived their well-fed peers by as much as 40 percent. But just how a diet verging on the brink of starvation extends lifespan has remained elusive. ...> Full Article Flu Gene Database Speeds ID And Tracking Of Emerging Influenza Strains (4/30/2007)A Medical College of Wisconsin and Children's Research Institute team in Milwaukee has created a free, searchable genetic database that will significantly improve diagnostic testing and genetic tracking of human and animal influenza viruses. The site, which is automatically updated weekly, will also facilitate rapid response as new virus strains emerge to cause either annual epidemics or the next pandemic. ...> Full Article Study Identifies New Genetic Risk Factors For Type 2 Diabetes (4/28/2007)Ten genetic variants associated with type 2 diabetes, a disease which impacts more than 170 million people worldwide, have been identified or confirmed by a U.S.-Finnish team led by scientists at the University of Michigan School of Public Health. ...> Full Article Clinic Discovers Dna Repair As Key To Huntington's Disease (4/23/2007)Poor gene repair may point to cause of incurable disease ...> Full Article Intravenous Nanoparticle Gene Therapy Shows Activity in Stage IV Lung Cancer (4/23/2007)A cancer-suppressing gene has been successfully delivered into the tumors of stage 4 lung cancer patients via an intravenously administered lipid nanoparticle in a phase I clinical trial at The University of Texas M. D. Anderson Cancer Center. The gene, FUS1, also was found to be active in the metastatic non-small cell lung cancer tumors. ...> Full Article Gene That May Be A Marker Of Breast Cancer Metastasis Identified (4/23/2007)Researchers at Fox Chase Cancer Center have identified an important gene involved in the spread of breast cancer that has developed resistance to long-term estrogen deprivation. The discovery was reported in an oral presentation during the 97th Annual Meeting of the American Association for Cancer Research in Los Angeles. The gene may prove to be a useful marker for predicting which patients have the greatest risk of breast cancer recurrence so their doctors can offer the most appropriate treatment plan. ...> Full Article Twin Studies Reveal Genetic Components (4/20/2007)Daniel O’Connor, M.D., Professor of Medicine and Pharmacology at the University of California, San Diego (UCSD) School of Medicine has studied about 265 twin pairs over the past few years, which has led him to some surprising discoveries. ...> Full Article Cancer-Initiating Stem Cells Taking a Larger Role in Cancer Treatment (4/20/2007)Recent discoveries about the role of stem cells in cancer have altered the landscape of cancer research. With each new study, scientists are learning more about cancer-initiating properties of stem cells at organ sites and throughout the body. Increasingly, stem cells are examined as the cause - and potential target of treatment - for many, if not all, cancers. ...> Full Article Bird Flu Genome Study Shows New Strains Spreading West (4/19/2007)
New Analysis On Two Countries' Models To Tackle Genetic Testing For Breast Cancer (4/15/2007)The United States and Great Britain have taken profoundly different approaches in developing genetic testing for breast cancer which has serious implications for users of health care, says a University of Michigan professor. ...> Full Article A Genetic 'Gang of Four' Drives Spread of Breast Cancer (4/13/2007)Studies of human tumor cells implanted in mice have shown that the abnormal activation of four genes drives the spread of breast cancer to the lungs. The new studies by Howard Hughes Medical Institute researchers reveal that the aberrant genes work together to promote the growth of primary breast tumors. Cooperation among the four genes also enables cancerous cells to escape into the bloodstream and penetrate through blood vessels into lung tissues. ...> Full Article Study Pries Into Ovarian Cancer's Deadly Secrets (4/12/2007)Defects in two cell-messaging systems work in sync in one common form of the disease, University of Michigan study finds ...> Full Article Discovery Raises Questions About Therapies Designed to Treat Half of all Human Cancers (4/10/2007)
Gene Mutation Linked to Hereditary Lung Disease (4/2/2007)Scientists at Johns Hopkins have identified the genetic culprits that trigger a hereditary form of a fatal lung disease. ...> Full Article Fruit Fly Gene Research May Shed Light On Human Disease (3/31/2007)Those small fruit flies buzzing around your bananas are more than pests—they may be allies in a fruitful search for clues to human diseases caused when genes malfunction. ...> Full Article Leukemic cells find safe haven in bone marrow (3/28/2007)The cancer drug asparaginase fails to help cure some children with acute lymphoblastic leukemia (ALL) because molecules released by certain cells in the bone marrow counteract the effect of that drug, according to investigators at St. Jude Children's Research Hospital. ...> Full Article Notorious Cancer Gene May Work By Destroying Messenger (3/20/2007)A new study suggests how a notorious cancer gene may contribute to tumor growth ...> Full Article Marine Moss Reveals Clues To Anti-Cancer Compound (3/13/2007)
Protein prevents wrinkles but causes cancer (3/9/2007)Researchers from BRIC, University of Copenhagen, have identified some of the key molecular mechanisms that trigger cancer and aging. When the level of a certain protein becomes too low, the cells age. However, when the levels are increased, the risk for the development of cancer is also increased. That impedes aging, but increases the risk of cancer. The results are published in the current issue of Genes & Development. ...> Full Article Gene reactivation shrinks Tumors (1/25/2007)Two groups of researchers, from New York's Cold Spring Harbor Laboratory and the Massachusetts Institute of Technology (MIT) in Cambridge have developed a method of reducing the size of tumors in mice by reactivating a gene, that when turned off appears to cause several forms of cancer. ...> Full Article Researchers discover Gene Associated With Severe Kidney Failure due to Diabetes (1/10/2007)A research team at Wake Forest University Baptist Medical Center and the University of Heidelberg, led by Barry I. Freedman, M.D. has linked a gene that protects some people with diabetes from evolving into severe kidney failure often called end-stage renal disease. ...> Full Article Inherited Pancreatic Cancer Gene Found (12/12/2006)Teri Brentnall with the University of Washington and David Whitcomb with the University of Pittsburgh has identified at least one of the gene's involved in inherited pancreatic cancer. ...> Full Article Risk of Heart Disease Linked to Genes and Diet (10/11/2006)Researchers with the Jean Mayer USDA Human Nutrition Research Center at Tufts University have found a link in genes involving heart disease and diet. The research examined apolipoprotein A5 (APOA5), a gene that creates a protein that controls the metabolism of fats in the blood. The results indicate that people carrying a specific variant of APOA5 may have an increased risk of heart disease, but only if they ate high amounts of omega-6 fatty acids. ...> Full Article Mouse regenerates injuries fast (4/11/2006)Professor Elen Heber-Katz a scientist with the Wistar Institute in Philadelphia has discovered a type of mouse that can regenerate injuries much faster than most other mammals. The mouse type, know as Murphy Roths Large (MRL) has opened up a new area of study that hopes to find and transfer the gene or genes to other mammals. ...> Full Article Loans - Flights - Loans - Credit Cards |
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