All Articles Tagged As: brain

Childhood brain tumor traced to normal stem cells gone bad (8/12/2008)

An aggressive childhood brain tumor known as medulloblastoma originates in normal brain "stem" cells that turn malignant when acted on by a known mutant, cancer-causing oncogene ...> Full Article

Researchers hone technique to KO pediatric brain tumors (7/19/2008)

Researchers a step closer to delivering cancer-killing drugs to pediatric brain tumors ...> Full Article

Models help scientists understand brain cancer (6/27/2008)

Transplanting brain cancer cells directly into similar tissues of immune-deficient mice created a model for the disease that preserved the brain tumor stem cells from which the cancers derived ...> Full Article

Vaccine May Double Survival in Patients with Deadly Brain Tumors (6/4/2008)

A vaccine aimed at inducing immunity to the most common and deadly type of brain tumor may stave off recurrence and more than double survival in patients ...> Full Article

Too many gene copies stimulate tumor cell growth (4/11/2008)

New data has characterized a molecular pathway underlying low-grade forms of a type of brain tumor known as an astrocytoma ...> Full Article

New regulatory circuit identified for aggressive, malignant brain tumor (4/10/2008)

Research using a newly developed algorithm has significantly advanced understanding of the molecular events associated with the most common primary brain tumor in adults, human glioblastoma ...> Full Article

Brain Tumor Patients Benefit From Chemotherapy Pill (4/7/2008)

At home chemotherapy pill may be useful for brain tumor patients ...> Full Article

Human breast tumors' 'microenvironment' primes them for metastasis (4/7/2008)

The environment within primary breast tumors can 'empower' cells that break free and enter the bloodstream to successfully invade other organs ...> Full Article

New research to unlock mysteries of brain cancer, stroke (4/7/2008)

New studies will delve into some of the crucial issues surrounding death by brain tumours and stroke ...> Full Article

New insight into the genetics of brain tumor formation (3/20/2008)

Researchers identify a potential new neuronal tumor suppressor ...> Full Article

Lab Engineers Virus That Can Kill Deadly Brain Tumors (2/23/2008)

A laboratory-engineered virus that can find its way through the vascular system and kill deadly brain tumors has been developed by Yale School of Medicine researchers, it was reported this week in the Journal of Neuroscience. ...> Full Article

Brain Damage Occurs Within Minutes from the Onset of a Stroke, Study Reveals (2/15/2008)

Scientists at the Brain Research Centre at the University of British Columbia and Vancouver Coastal Health Research Institute have found that harmful changes to the brain's synaptic connections occur within the first three minutes following a stroke. ...> Full Article

Gene plays 'Jekyll and Hyde' in brain cancer (2/7/2008)

Perhaps the only positive spin one can put on the brain cancer glioblastoma is that it's relatively uncommon. Other than that, the news is bad. It is nearly always fatal, it tends to strike people in the prime of their lives, and the limited treatment options have changed little over decades. It's no wonder then that many researchers are determined to find new ways treat this poorly understood type of cancer. ...> Full Article

New Brain Tumor Treatments Offer Hope (2/2/2008)

In 2008, approximately 215,000 Americans will be diagnosed with one of more than 100 types of brain tumors. Patients who receive such a diagnosis should remain hopeful, however, as treatment options at the nation's leading brain tumor centers have never been better, according to Philip Theodosopoulos, MD, assistant professor of neurosurgery and director of the division of skull base surgery at the University of Cincinnati (UC). ...> Full Article

Drug Helps Brain Tumor Patients Live Longer (1/30/2008)

People who receive high doses of the chemotherapy drug methotrexate to treat a certain type of brain tumor appear to live longer than people receiving other treatments, according to research published in the January 29, 2008, issue of Neurology®, the medical journal of the American Academy of Neurology. ...> Full Article

Combined Radiation Seed, Chemotherapy Wafer Implantation May Help Treat Brain Tumors (1/19/2008)

In the battle against malignant brain tumors, dual implantation of radioactive seeds and chemotherapy wafers following surgery showed promising results in a study led by specialists at the Neuroscience Institute at the University of Cincinnati (UC) and University Hospital. ...> Full Article

Immature Brain Cell Errors May Promote Brain Tumor Growth (1/9/2008)

In experiments done in lab and animal studies, a breakdown in proper cell development has been shown to cause brain-specific stem cells to become starter seeds for aggressive brain tumors called glioblastoma multiforme, according to research from a team of researchers at the National Cancer Institute (NCI) and the National Institute of Neurological Disease and Stroke (NINDS), parts of the National Institutes of Health (NIH). ...> Full Article

Research Suggests New Treatment Suitable for All Patients With Least-Curable Brain Tumors (1/2/2008)

New research at Wake Forest University Baptist Medical Center suggests that a three-drug cocktail may one day improve outcomes in patients with glioblastoma multiforme (GBM), a type of brain tumor with a dismal prognosis. Two of the drug candidates have been developed, and the team is working on the third - all targeted to kill or impair cancer cells and spare healthy brain. ...> Full Article

New Method of Drug Delivery More Effective at Reaching Brain Tumors (11/28/2007)

Bioengineers at Yale and Cornell have created a modified chemotherapy that more effectively reaches and remains at the site of brain tumors - by adding a water-soluble polymer to the anti-cancer drug, according to a report in the November-December issue of Bioconjugate Chemistry. ...> Full Article

Researchers test novel vaccine to treat aggressive brain tumors (10/28/2007)

New vaccine for glioblastoma multiforme, an aggressive brain cancer, is now being offered through a clinical trial at Mayo Clinic in Jacksonville. ...> Full Article

Direct Route From The Brain To The Immune System Discovered (10/25/2007)

Scientists find out that the brain talks directly to the immune system, sending commands that control the body's inflammatory response to infection and autoimmune diseases. Understanding the intimate relationship is leading to a novel way to treat diseases triggered by a dangerous inflammatory response. ...> Full Article

Common Virus May Help Doctors Treat Deadly Brain Tumors (10/24/2007)

A common human virus may prove useful in attacking the deadliest form of brain tumors, according to study conducted by researchers at Duke's Preston Robert Tisch Brain Tumor Center. The researchers said the finding is an important step in developing a vaccine that can attack the tumors by enlisting the help of the body's immune system. ...> Full Article

Study suggests brain tumors need treatment with multiple targeted drugs (9/17/2007)

Researchers have shown that several, rather than just one, cell-growth switches are simultaneously overactive in many brain tumors and other solid tumors, explaining why treatment with just a single "targeted" switch-blocking drug often yields disappointing results. The laboratory finding argues for quickly moving to clinical trials that combine three or more such targeted drugs for such cancers to shut down all the malfunctioning growth switches. ...> Full Article

Customized Virus Kills Brain Tumor Stem Cells that Drive Lethal Cancer (9/14/2007)

A tailored virus destroys brain tumor stem cells that resist other therapies and cause lethal re-growth of cancer after surgery, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports in the Sept. 18 edition of the Journal of the National Cancer Institute. ...> Full Article

Neural stem cell study reveals mechanism that may play role in cancer (9/8/2007)

In the dynamic world of the developing brain, neural stem cells give rise to neurons deep within the brain's fluid-filled ventricles. These newborn neurons then migrate along the stem cell fibers up to the neocortex, the seat of higher cognitive functions. Now, scientists have discovered a key mechanism of this migration - one that may also play an important role in other developmental processes and diseases, including cancer. ...> Full Article

Immunology Researchers Halt Lethal Rabies Infection in Brain (9/5/2007)

While rabies, an ancient scourge that still kills 70,000 every year in developing countries worldwide can be combated with a series of vaccines today, it nearly is always fatal when it reaches the brain. ...> Full Article

Research points to possible new stroke therapy (8/23/2007)

New research from an international team of scientists has identified a possible new therapy for stroke that is likely to be more effective than current treatments. ...> Full Article

Researchers Study Longterm Effects of Pediatric Brain Tumors (8/23/2007)

A team of researchers from Emory and Georgia State Universities has been awarded a four-year, nearly $850,000 grant from the American Cancer Society to study risk factors for long-term social and cognitive problems in adult survivors of pediatric brain tumors. The study will focus on more than 100 adults, currently in their 20s, who have survived at least ten years beyond their initial diagnosis. ...> Full Article

Natural protection provides possible new treatments for stroke (8/22/2007)

Two substances that occur naturally in the brain act to protect the brain during a stroke. This is the conclusion of a dissertation published at the Sahlgrenska Academy, and the discovery may lead to new treatments for stroke patients. ...> Full Article

Invasion Of The Brain Tumors: Regulator Discovered (8/21/2007)

Gliomas are highly malignant and invasive tumors with tendrils that extend far from the primary tumor site, rendering conventional therapies ineffective and leading to an invariably poor prognosis. ...> Full Article

Physician-scientists pinpoint how cancer spreads within the brain (8/15/2007)

Team finds "switch" that sparks cancer cells to travel ...> Full Article

Study Investigating Vaccine to Treat Brain Tumors Underway (8/5/2007)

Researchers at the University of Pennsylvania School of Medicine and the Abramson Cancer Center have begun ACT III – a Phase II/III Randomized Study – to investigate the addition of CDX-110 vaccine to standard care maintenance chemotherapy in patients with newly diagnosed glioblastoma multiforme (GBM), the most aggressive form of primary brain tumor. ...> Full Article

Brain Discovery Could Fight Deadly Tumors (7/21/2007)

MIT researchers have identified a critical link between two proteins found in brain tumors, a discovery that could eventually help treat a form of brain cancer that kills 99 percent of patients. ...> Full Article

Frog Molecule Could Provide Drug Treatment For Brain Tumors (6/29/2007)

A synthetic version of a molecule found in the egg cells of the Northern Leopard frog (Rana pipiens) could provide the world with the first drug treatment for brain tumours. ...> Full Article

Vorinostat Shows Anti-Cancer Activity in Recurrent Gliomas (6/11/2007)

North Central Cancer Treatment Group (NCCTG) researchers, based at Mayo Clinic in Rochester, Minn., report that a novel application of the drug vorinostat shows activity in patients with recurrent glioblastoma multiforme. These findings were presented today at the American Society of Clinical Oncology Annual Meeting by Eva Galanis, M.D., a Mayo Clinic oncologist and lead investigator of the study. ...> Full Article

Brain Tumor Vaccine Developed By Stanford Researcher To Be Tested At 20 Sites Nationally (5/24/2007)

An experimental vaccine developed by a researcher at the Stanford University School of Medicine to treat a rapidly fatal brain tumor called glioblastoma will be tested in 20 U.S. sites including Stanford. ...> Full Article

Discovery May Change Thinking On How Viruses Invade The Brain (4/24/2007)

A molecule thought crucial to ferrying the deadly rabies virus into the brain, where it eventually kills, apparently isn't. The surprising finding, say researchers at Jefferson Medical College in Philadelphia, may change the way scientists think about how central nervous system-attacking viruses such as herpes viruses invade the brain and cause disease. ...> Full Article