All Articles Tagged As: aging

Mouse Study: When It Comes To Living Longer, It's Better To Go Hungry Than Go Running (5/16/2008)

A study investigating aging in mice has found that hormonal changes that occur when mice eat significantly less may help explain an already established phenomenon: a low calorie diet can extend the lifespan of rodents, a benefit that even regular exercise does not achieve. ...> Full Article

Human aging gene found in flies (5/12/2008)

Scientists have found a fast and effective way to investigate important aspects of human aging ...> Full Article

Eliminating Germline Lengthens Fly Lifespan, Study Shows (4/26/2008)

Biologists have found that eliminating germline stem cells, the cells that make eggs and sperm, lengthens the life of fruit flies and alters the insects' insulin production ...> Full Article

Researchers uncover details about how dietary restriction slows down aging (4/18/2008)

Scientists have uncovered details about the mechanisms through which dietary restriction slows the aging process ...> Full Article

Researchers discover new effect for insulin (3/23/2008)

Plays previously unknown role in aging and lifespan ...> Full Article

New Longevity Genes Identified: Yeast, Worms And People May Age By Similar Mechanisms (3/19/2008)

Scientists have identified 25 genes regulating lifespan in two organisms separated by about 1.5 billion years in evolutionary change. At least 15 of those genes have very similar versions in humans, suggesting that scientists may be able to target those genes to help slow down the aging process and treat age-related conditions. ...> Full Article

Einstein researchers discover gene mutations linked to longer lifespans (3/10/2008)

Mutations in genes governing an important cell-signaling pathway influence human longevity, scientists at the Albert Einstein College of Medicine of Yeshiva University have found. ...> Full Article

Scientists develop tool to probe role of oxidative stress in aging, disease (2/18/2008)

Oxygen, although essential for human life, can turn into an aggressive chemical that is outright toxic to important molecules inside our cells. This "oxidative stress" is associated with many diseases, such as Alzheimer's, heart disease and cancer, and has been suggested to be the culprit underlying aging. ...> Full Article

Mitochondrial DNA mutations can cause degenerative heart and muscle disease (2/17/2008)

Study provides insights into age-related diseases and proof that mitochondrial DNA is central to health ...> Full Article

Studies Identify Modifiable Factors Associated With Exceptionally Long Life (2/12/2008)

A healthy lifestyle during the early elderly years-including weight management, exercising regularly and not smoking-may be associated with a greater probability of living to age 90 in men, as well as good health and physical function, according to a report in the February 11 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. A second article in the same issue finds that although some individuals survive to 100 years or beyond by avoiding chronic diseases, other centenarians live with such conditions for many years without becoming disabled. ...> Full Article

Sedentary Lifestyles Associated With Accelerated Aging Process (1/31/2008)

Individuals who are physically active during their leisure time appear to be biologically younger than those with sedentary lifestyles, according to a report in the January 28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. ...> Full Article

Live fast - but die when? (1/21/2008)

Most current theories of aging believe that our aging process is related to how fast we live - how many calories we eat and how many calories we expend. The notion of "live fast, die young" seems to make intuitive sense, but there's a new way of thinking that rejects this notion and suggests a whole new way of thinking about how the body manages energy. ...> Full Article

How Some Plants And Animals Appear To Defy The Aging Process (1/18/2008)

The inevitability of the aging process and the onset of senescence - the process of deterioration with age - is a fact of life for most plant and animal species. ...> Full Article

10-Fold Life Span Extension Reported (1/15/2008)

Record longevity for baker's yeast suggests strategies for helping humans live longer and healthier ...> Full Article

Lifestyle changes increase life expectancy 14 years (1/9/2008)

Four behaviours which can add an average of 14 years life expectancy have been identified in a study led by Cambridge University. ...> Full Article

New Scholar Award helps young researcher study age-related diseases (1/8/2008)

The Ellison Medical Foundation in Bethesda, Md., supports basic biomedical research on aging relevant to understanding lifespan development processes and age-related diseases and disabilities. ...> Full Article

New Ingredients in Drug-Like Anti-Aging Products Improve Skin (12/29/2007)

Cosmecueticals, beauty aids that reportedly work like prescription drugs, are providing new ways to treat aging skin. A study recently published in the Journal of Cosmetic Dermatology explores a variety of new ingredients in cosmeceuticals that provide a visibly noticeable improvement in maturing skin. ...> Full Article

Aging Gracefully Requires Taking Out The Trash (12/24/2007)

Suppressing a cellular cleanup-mechanism known as autophagy can accelerate the accumulation of protein aggregates that leads to neural degeneration. In an upcoming issue of Autophagy, scientists at the Salk Institute for Biological Studies report for the first time that the opposite is true as well: Boosting autophagy in the nervous system of fruit flies prevented the age-dependent accumulation of cellular damage in neurons and promoted longevity. ...> Full Article

Crawling Worms May Illuminate Dopamine's Role in Human Aging Diseases (12/18/2007)

Research carried out with a paintbrush bristle, a metronome, smelly chemicals and thousands of microscopic worms called nematodes may reveal important information about human aging diseases like Parkinson's and Alzheimer's, thanks to a grant from the Ellison Medical Foundation awarded to a University at Buffalo neurobiologist. ...> Full Article

A drink to healthy aging (12/17/2007)

A study by the University's Priority Research Centre for Gender, Health and Ageing, in collaboration with the Hunter Medical Research Institute's (HMRI) Public Health Program, indicates that moderate consumption of alcohol in older women, in line with Australian alcohol guidelines*, is associated with better survival and quality of life. ...> Full Article

Herbal extract found to increase lifespan (12/8/2007)

Fruit flies on Rhodiola diet live 10 percent longer, UCI study finds ...> Full Article

Study finds fitness level, not body fat, may be stronger predictor of longevity for older adults (12/6/2007)

Adults over age 60 who had higher levels of cardiorespiratory fitness lived longer than unfit adults, independent of their levels of body fat, according to a study in the December 5 issue of JAMA. ...> Full Article

Could hydrogen sulfide hold the key to a long life? (12/4/2007)

Study finds 'rotten egg' chemical increases life span and heat tolerance in worms ...> Full Article

Researchers produce short-term reversal of skin aging in mice (12/2/2007)

Researchers have reversed the effects of aging on the skin of mice, at least for a short period, by blocking the action of a single critical protein. ...> Full Article

Fat Hormone May Contribute To Longevity (11/25/2007)

Both humans and mice that manage to live to a ripe, old age show a clear change in their glucose metabolism, but it's unclear whether this change alone can increase lifespan. ...> Full Article

Antidepressant Found to Extend Lifespan in C. Elegans (11/22/2007)

A team of scientists have found that a drug used to treat depression can extend the lifespan of adult roundworms. ...> Full Article

Telomerase Enzyme Structure Provides Significant New Target for Anti-Cancer Therapies (11/18/2007)

Findings May Also Provide Insights into Normal Aging ...> Full Article

Stay fit to fight the aging process (11/15/2007)

Are you prepared to go to the gym for one hour, three times a week, for 20 weeks — all in the name of science? If so researchers at The University of Nottingham want to hear from you. ...> Full Article

Scientists hail the 'sunshine vitamin' (11/14/2007)

Scientists have found that vitamin D may be instrumental in protecting us against certain diseases, as well as helping to slow down the ageing process. ...> Full Article

Risk of disability increasing among older obese individuals (11/8/2007)

The older obese population in the U.S. appear to be experiencing more impairments in functional abilities related to movement, although there have been improvements in the cardiovascular health of this population. ...> Full Article

Ecologists Uncover Links Between Fever And Living Fast, Dying Young (11/4/2007)

Fever is an effective defence against disease, but new research suggests that not all animals use it when exposed to infection. The study, published online in the British Ecological Society's journal Functional Ecology, found large differences in fever responses among closely related species of mice and suggests that an animal's reproductive strategy could explain some of this intriguing variation. ...> Full Article

Severely Restricted Diet Linked To Physical Fitness Into Old Age (10/27/2007)

Severely restricting calories leads to a longer life, scientists have proved. New research now has shown for the first time that such a diet also can maintain physical fitness into advanced age, slowing the seemingly inevitable progression to physical disability and loss of independence. ...> Full Article

A Longer-living, Healthier Mouse That Could Hold Clues To Human Aging (10/24/2007)

A study by scientists in the UK show that mice lacking the insulin receptor substrate (IRS)-1 are more resistant to aging than normal mice. The research adds to a growing body of work showing the importance of insulin signaling pathways as an aging mechanism in mammals - and potentially humans. ...> Full Article

Genes That Both Extend Life And Protect Against Cancer Identified (10/18/2007)

A person is 100 times more likely to get cancer at age 65 than at age 35. But new research reported today in the journal "Nature Genetics" identifies naturally occurring processes that allow many genes to both slow aging and protect against cancer in the much-studied C. elegans roundworm. ...> Full Article

Gene Believed To Promote Long Life Linked To Cholesterol Flushing (10/15/2007)

Researchers have discovered a link between a gene believed to promote long lifespan and a pathway that flushes cholesterol from the body. ...> Full Article

Avoiding Sweets May Spell A Longer Life, Study In Worms Suggests (10/10/2007)

A new study reveals that worms live to an older age when they are unable to process the simple sugar glucose. Glucose is a primary source of energy for the body and can be found in all major dietary carbohydrates as a component of starches and other forms of sugar, including sucrose (table sugar) and lactose. ...> Full Article

Ugly duckling mole rats might hold key to longevity (10/5/2007)

Methusalah of the mammalian kingdom ...> Full Article

Unlocking the secrets of aging (10/4/2007)

You've heard that anti-oxidants are good for us - but do you know why? ...> Full Article

Eat Less To Live Longer: Calorie Restriction Linked To Long Healthy Lives (9/26/2007)

For nearly 70 years scientists have known that caloric restriction prolongs life. In everything from yeast to primates, a significant decrease in calories can extend lifespan by as much as one-third. But getting under the hood of the molecular machinery that drives this longevity has remained elusive. ...> Full Article

NIH Awards Einstein Researcher Multi-Million Dollar Grant To Extend Our Understanding of Exceptional Longevity (9/18/2007)

Albert Einstein College of Medicine of Yeshiva University has been awarded a grant of more than $9.25 million from the National Institutes of Health to further the medical school's study of centenarians and the biology of aging. ...> Full Article

U.S. Life Expectancy Hits New High of Nearly 78 Years (9/16/2007)

A child born in the United States in 2005 can expect to live nearly 78 years (77.9) - a new high - according to a report released today by the Centers for Disease Control and Prevention, "Deaths: Preliminary Data for 2005." ...> Full Article

Men shed light on the mystery of human longevity (9/13/2007)

It turns out that older men chasing younger women contributes to human longevity and the survival of the species, according to new findings by researchers at Stanford and the University of California-Santa Barbara. ...> Full Article

In Matters Of Sex And Death, Men Are An Essential Part Of The Equation (9/2/2007)

Stanford scientists show in a forthcoming paper that traditional mating patterns make men the key to explaining away the "wall of death," an enduring puzzle in the study of human longevity. ...> Full Article

Researchers Uncover Genetic Components of Aging (8/27/2007)

People who live to 100 or more are known to have just as many-and sometimes even more-harmful gene variants compared with younger people. Now, scientists at the Albert Einstein College of Medicine of Yeshiva University have discovered the secret behind this paradox: favorable "longevity" genes that protect very old people from the bad genes' harmful effects. The novel method used by the researchers could lead to new drugs to protect against age-related diseases. ...> Full Article

Scientists reveal how dietary restriction cleans cells (8/24/2007)

Reduce, recycle and rebuild is as important to the most basic component of the human body, the cell, as it is to the environment. And a University of Florida study shows just how much the body benefits when it "goes green," at least if you're a rat: Cutting calories helps rodents live longer by boosting cells' ability to recycle damaged parts so they can maintain efficient energy production. ...> Full Article

Answers to Aging from the Amish (8/11/2007)

Is your time up when your telomeres wind down? ...> Full Article

Study Finds No Cause-and-Effect Link Between Microbes And Aging (8/10/2007)

Bacteria - you can live without 'em, but it won't do you any good, according to a study of fruit flies by USC biologists. ...> Full Article

Kerrigan's Unique Research May Unlock Elder Gait Enigma (8/7/2007)

D. Casey Kerrigan, M.D., professor and chair of the Department of Physical Medicine and Rehabilitation, may have discovered the "holy grail" of physical aging research. Kerrigan's novel analysis of the deterioration of gait—or walking—in older adults has attracted a major National Institutes of Health (NIH) grant. ...> Full Article

Throttling Up Tiny Power Plants May Protect Nerve Cells (7/28/2007)

Revving up the "mini-energy factories" in central nervous system cells appears to help insulate them from damage caused by reactive oxygen species, which are believed to be prime culprits in aging. That is one of the findings from a new study conducted at The University of Texas Health Science Center at San Antonio. ...> Full Article

Reducing Insulin Signaling In The Brain Can Prolong Lifespan (7/23/2007)

Study explains the physiologic benefits of diet and exercise ...> Full Article

Gene Deficiency is a Protective Barrier to Obesity (7/2/2007)

A search for the molecular clues of longevity has taken Mayo Clinic researchers down another path that could explain why some people who consume excessive calories don't gain weight. The study, which was done in laboratory mouse models, points to the absence of a gene called CD38. When absent, the gene prevented mice on high-fat diets from gaining weight, but when present, the mice became obese. ...> Full Article

Biologists Link Calorie Restriction To An Extended Life Span (6/19/2007)

The link between calorie restriction and a longer, healthier life may lie in the head, not in the gut, MIT biologists report. ...> Full Article

Dna Damage To Stem Cells Is Central To Aging (6/11/2007)

DNA damage is a major mechanism behind the loss of adult stem cells over time, according to a Nature paper by Oxford University researchers and international colleagues. ...> Full Article

Aging Of Fruit Fly Slowed With Single Protein Addition (6/10/2007)

In a triumph for pests, scientists have figured out how to make the fruit fly live longer. ...> Full Article

Loss of Stem Cells Correlates with Premature Aging in Animal Study (6/9/2007)

Researchers at the Abramson Family Cancer Research Institute of the University of Pennsylvania have found that deleting a gene important in embryo development leads to premature aging and loss of stem cell reservoirs in adult mice. This gene, ATR, is essential for the body's response to damaged DNA, and mutations in proteins in the DNA damage response underlie certain types of cancer and other disorders in humans. This work appears in the inaugural issue of Cell Stem Cell. ...> Full Article

Male Mice Get A Longevity Boost From Compound Found In Creosote Bush (6/6/2007)

Aspirin didn't pan out. Neither did two other potential anti-aging agents. But a synthetic derivative of a pungent desert shrub is now a front- runner in ongoing animal experiments to find out if certain chemicals, known to inhibit inflammation, cancer and other destructive processes, can boost the odds of living longer. ...> Full Article

Study Shows Exercise May Reverse Aging Process (5/25/2007)

A new study provides more evidence of how exercise can pump up your quality of life as you age, and even help reverse the aging process. ...> Full Article

Change In Neuroticism Tied To Mortality Rates (5/21/2007)

While mellowing with age has often been thought to have positive effects, a Purdue University researcher has shown that doing so could also help you live longer. ...> Full Article

Vitamin Extends Life In Yeast May Apply To Humans (5/7/2007)

Imagine taking a vitamin for longevity! Not yet, but a Dartmouth discovery that a cousin of niacin prolongs lifespan in yeast brings the tantalizing possibility a step closer. ...> Full Article

Researchers Discover First Gene That Specifically Links Calorie Restriction To Longevity (5/3/2007)

In studies going back to the 1930's, mice and many other species subsisting on a severely calorie-restricted diet have consistently outlived their well-fed peers by as much as 40 percent. But just how a diet verging on the brink of starvation extends lifespan has remained elusive. ...> Full Article

High Melatonin Content Can Help Delay Aging (4/25/2007)

A study carried out by researchers from the University of Granada’s Institute of Biotechnology shows that consuming melatonin neutralizes oxidative damage and delays the neurodegenerative process of aging. In this study researchers used normal and genetically-modified mice which were subjected to accelerated cell aging. Researchers believe their results can also be applied to humans. ...> Full Article

Our Genes Evolved In A Way So That Their Is No Solution To Cancer (4/18/2007)

Cancer is a natural consequence of human evolution. Our genes have not developed to give us long and happy lives. They are optimized to copy themselves into the next generation - irrespective of our personal desires. According to Jarle Breivik, an associate professor at the University of Oslo, Norway, we are therefore unlikely to find a final solution to cancer. ...> Full Article

Eating less will make you live longer (4/5/2007)

Much research has shown that reduced calorie intake can increase health and longevity. Professor Stephen Spindler (University of California) and his collaborators* have discovered that reducing calorie intake later in life can still induce many of the health and longevity benefits of life-long calorie reduction. Importantly, this also includes anti-cancer effects. ...> Full Article

Resveratrol Doubles Endurance and Extends Life (11/22/2006)

Dr. Johan Auwerx and colleagues at the Institute of Genetics and Molecular and Cellular Biology in Illkirch, France have published a report in the journal Cell about a drug that doubles the physical endurance of mice running on treadmills. The drug, called Resveratrol, has also been found in other studies to increase a mouse's life span by up to 30%. ...> Full Article