Lessons from neuroscience in treating heart disease (11/20/2007)

Scientists have found a naturally occurring protein, known as nerve growth factor, can dramatically improve the survival of heart cells.

Nerve growth factor (NGF) was once thought to act only on nerve cells in the body, but this study shows that it can have a protective effect on heart muscle cells in a heart attack model â€" the first time this has been shown.

The research, published in the current online issue of the journal Cell Death and Differentiation, was funded by the British Heart Foundation and led by Dr Costanza Emanueli, Senior Research Fellow at Bristol University and her colleagues at the Bristol Heart Institute.

Growth factors are naturally occurring proteins that stimulate normal body processes of cell growth, division and differentiation. Some act on many different cell types within the body, whereas others are specific for a particular type of cell. NGF normally controls nerve cell survival and regeneration and was for a long time of interest only to neuroscientists.

Dr Emanueli’s group at the Bristol Heart Institute, based in the Bristol Royal Infirmary, first performed in vitro studies showing that NGF was protective in cultures of heart cells. They then expanded these studies to a heart attack model in rats, which closely mimics what happens in a heart attack in humans, by tying off one of the arteries supplying the heart with blood.

In a human, this would happen as a result of a sudden blockage of the artery due to a build-up of cholesterol and fatty material within a blood vessel rupturing and blocking the artery. This causes a massive cell death in the immediate region of the blockage, but also has a later effect in causing cell death in the area around the blockage. This results in the remaining live cells in that area having to adapt by increasing in size, leading to enlargement of the heart and eventual heart failure.

Dr Emanueli found that injecting the gene for NGF into the region around the dead cell area promoted survival of the cells in that region, compared to hearts not treated with NGF, a week following injection of the NGF gene.

Dr Emanueli, commenting on the research, said: “This is the first time that a pro-survival effect in the heart of NGF has been found. Some other growth factors are already used clinically to treat different diseases, and our study shows that NGF may be a novel way of protecting the heart from further damage following a heart attack.“

Note: This story has been adapted from a news release issued by Bristol University

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