Curing Death by Curing Aging Archives Page 26

Lung Cancer Cells' Survival Gene Seen as Drug Target (1/4/2008)

One of the deadliest forms of cancer appears to carry a specific weakness. When a key gene called 14-3-3zeta is silenced, lung cancer cells can't survive on their own, researchers have found. ...> Full Article

Researchers Show that Fibrosis can be Stopped, Cured and Reversed Modified Protein May Lead to First Cure for Cirrhosis of the Liver (1/3/2008)

Researchers have proven in animal studies that fibrosis in the liver can be not only stopped, but reversed. Their discovery, to be published in PLoS Online on December 26, opens the door to treating and curing conditions that lead to excessive tissue scarring such as viral hepatitis, fatty liver disease, cirrhosis, pulmonary fibrosis, scleroderma and burns. ...> Full Article

Gene variation may elevate risk of liver tumor in patients with cirrhosis (1/3/2008)

Growth factor pathway may be target for preventive treatment ...> Full Article

Cancer Cell Line Developed That Is Resistant To New Cancer Therapy (1/3/2008)

A cancer cell line that is resistant to one of the newest classes of cancer treatments has been developed by researchers who already are using it to determine what else to give patients when this happens. ...> Full Article

Potential Drug Target For Treatment-resistant Prostate Cancer Discovered (1/2/2008)

Scientists at Jefferson's Kimmel Cancer Center in Philadelphia have found that a signaling protein that is key to prostate cancer cell growth is turned on in nearly all recurrent prostate cancers that are resistant to hormone therapy. If the findings hold up, the protein, called Stat5, may be a specific drug target against an extremely difficult-to-treat cancer. ...> Full Article

Research Suggests New Treatment Suitable for All Patients With Least-Curable Brain Tumors (1/2/2008)

New research at Wake Forest University Baptist Medical Center suggests that a three-drug cocktail may one day improve outcomes in patients with glioblastoma multiforme (GBM), a type of brain tumor with a dismal prognosis. Two of the drug candidates have been developed, and the team is working on the third - all targeted to kill or impair cancer cells and spare healthy brain. ...> Full Article

Restless Legs Syndrome Doubles Risk of Stroke and Heart Disease (1/2/2008)

People with restless legs syndrome (RLS) are twice as likely to have a stroke or heart disease compared to people without RLS, and the risk is greatest in those with the most frequent and severe symptoms, according to research published in the January 1, 2008, issue of Neurology®, the medical journal of the American Academy of Neurology. ...> Full Article

Overeating And Obesity Triggered By Lack Of One Gene (1/1/2008)

According to the Centers for Disease Control and Prevention, close to one-third of the population in the United States is obese and another third is overweight. Excessive weight gain is elicited by alterations in energy balance, the finely modulated equilibrium between caloric intake and expenditure. But what are the factors that determine how much food is consumed? ...> Full Article

Scientists Discover New Role For MiRNA In Leukemia (1/1/2008)

Scientists here have found that mini-molecules called micro-RNA may play a critical role in the progression of chronic myeloid leukemia (CML) from its more treatable chronic phase to a life-threatening phase, called blast crisis. ...> Full Article

Breast Cancer Cells Have To Learn To Walk Before They Can Run (1/1/2008)

Early-stage breast cancer that has not yet invaded the surrounding tissues may already contain highly motile cells, bringing the tumor one step closer to metastasis, report researchers at the Salk Institute for Biological Studies. ...> Full Article

Two Genes Are Important Key to Regulating Immune Response (12/31/2007)

Pbx-1, Prep-1 Help Spur IL-10 Production; Findings Have Implications for Research into Lupus, Cancer and HIV/AIDS ...> Full Article

Researchers Hot on the TRAIL of New Cancer Targets (12/30/2007)

Cell-Death Receptor Link Between Cancer Susceptibility and Inflammation ...> Full Article

New Ingredients in Drug-Like Anti-Aging Products Improve Skin (12/29/2007)

Cosmecueticals, beauty aids that reportedly work like prescription drugs, are providing new ways to treat aging skin. A study recently published in the Journal of Cosmetic Dermatology explores a variety of new ingredients in cosmeceuticals that provide a visibly noticeable improvement in maturing skin. ...> Full Article

New Drug Targets May Fight Tuberculosis and Other Bacterial Infections in Novel Way (12/29/2007)

Research Into 'Virulence Factors' Expands War Against Infectious Disease Beyond Antibiotics ...> Full Article

Breast cancer gene mutation more common in Hispanic, young black women (12/28/2007)

A genetic mutation already known to be more common in Ashkenazi Jewish breast cancer patients is also prevalent in Hispanic and young African-American women with breast cancer, according to one of the largest, multiracial studies of the mutation to date. ...> Full Article

Biomarker could lead to new treatment for cancer and Crohn's disease (12/28/2007)

Cambridge Enterprise Limited, the commercialisation office of the University of Cambridge, has completed a licence agreement with Medarex, Inc. for the potential development of a therapeutic drug to treat cancer and autoimmune diseases. ...> Full Article

Sea cucumber protein used to inhibit development of malaria parasite (12/27/2007)

Scientists have genetically engineered a mosquito to release a sea-cucumber protein into its gut which impairs the development of malaria parasites, according to research out today (21 December) in PLoS Pathogens. Researchers say this development is a step towards developing future methods of preventing the transmission of malaria. ...> Full Article

New Research Tools Suggest Cancer And Other Diseases Are Too Complex For Easy Answers, Researchers Say (12/27/2007)

Scientists who study cancer may be prone to drawing simplistic conclusions from the powerful molecular tools now available because they don't appreciate how complex the data is that is being generated, said a team of Georgetown University Medical Center (GUMC) researchers in the January issue of Nature Reviews Cancer. ...> Full Article

New thermal-imaging technique may help victims of head and neck cancers (12/27/2007)

When University of Chicago head-and-neck cancer researcher Cindy Bajda felt a raised bump on the bottom of her mouth, she'd spent too much time around oral cancer patients to have any doubt as to her diagnosis. ...> Full Article

Researchers Initiate Gene Therapy Trial in Patients with Advanced Skin Cancer (12/26/2007)

Researchers at the Ireland Cancer Center of University Hospitals Case Medical Center are the first in the region to have joined a nationwide clinical trial to evaluate the effectiveness of a gene therapy in patients with advanced melanoma which is aimed to help a patient's own immune system fight their cancer. ...> Full Article

Scientists develop new drug candidate to outflank cancer resistance (12/25/2007)

A new drug candidate first synthesized by scientists in the Medicinal Chemistry Group at the University of Bath has shown promising experimental results against breast and prostate cancer cells and tumours that are resistant to conventional hormone-based treatments. ...> Full Article

Light powered platinum more targeted and 80 times more powerful than similar cancer treatments (12/25/2007)

Researchers have discovered a new light-activated platinum-based compound that is up to 80 times more powerful than other platinum-based anti-cancer drugs and which can use "light activation" to kill cancer cells in much more targeted way than similar treatments. ...> Full Article

First Look at an Enzyme Target for Antibacterial and Cancer Drugs (12/25/2007)

The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication, and is a prime target of antibacterial and anticancer drugs. Researchers with the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) at Berkeley have produced the first three-dimensional structural images of a DNA-bound Type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. ...> Full Article

Cancer Stem Cells: Know Thine Enemy (12/24/2007)

Stem cells-popularly known as a source of biological rejuvenation-may play harmful roles in the body, specifically in the growth and spread of cancer. Amongst the wildly dividing cells of a tumor, scientists have located cancer stem cells. Physician-scientists from Weill Cornell Medical College are studying these cells with hopes of combating malignant cancers in the brain. ...> Full Article

Researchers find link between cellular defense processes, showing how cancer cells survive (12/24/2007)

investigators have discovered that immune system cells that engulf and destroy germs in the body enlist help for this task from a common housekeeping mechanism that most cells use to keep their interiors healthy, a finding that is likely to help researchers understand how the body defends itself against infections and how cancer cells can resist chemotherapy drugs before they have a chance to work. ...> Full Article

Aging Gracefully Requires Taking Out The Trash (12/24/2007)

Suppressing a cellular cleanup-mechanism known as autophagy can accelerate the accumulation of protein aggregates that leads to neural degeneration. In an upcoming issue of Autophagy, scientists at the Salk Institute for Biological Studies report for the first time that the opposite is true as well: Boosting autophagy in the nervous system of fruit flies prevented the age-dependent accumulation of cellular damage in neurons and promoted longevity. ...> Full Article

Microchip-based device can detect rare tumor cells in bloodstream (12/23/2007)

Blood 'biopsy' may provide information to guide treatment planning, monitor response ...> Full Article

High-Fat, High-Carb Meal More Destructive to the Obese (12/23/2007)

Increase in already high free radicals significantly raises heart-attack risk ...> Full Article

New insights into deadly heart rhythm disorder (12/23/2007)

Better ways to identify people at risk for ventricular fibrillation could arise from U-M/SUNY group's work showing universal law of electrical turbulence in the heart ...> Full Article

Attention Guys - Testicular Cancer Isn't as Rare as You Think (12/22/2007)

Paying closer attention to the look and feel of your testicles could be a lifesaver. ...> Full Article