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Curing Death by Curing Aging - February 2009 ArchivesResearchers report breakthrough in HPV research (2/28/2009)UAB researchers have developed a new, inexpensive and efficient method for producing and studying a type of human papillomavirus that causes cervical cancer. The process could speed understanding of how the virus functions and causes diseases, and lead to new prevention or treatment options. ...> Full Article Male infertility associated with testicular cancer (2/28/2009)Men who are infertile appear to have an increased risk of developing testicular cancer, according to a report in the Feb. 23 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. ...> Full Article Metastasis-promoting protein identified; could provide a prognostic test or target for breast cancer (2/28/2009)Protein detectable in urine predicts invasiveness ...> Full Article Arsenic and old toenails (2/27/2009)New research highlights environmental exposure to toxin ...> Full Article Lowering your cholesterol may decrease your risk of cancer (2/27/2009)Current research suggests that lowering cholesterol may block the growth of prostate tumors. The related report by Solomon et al, "Ezetimibe Is an Inhibitor of Tumor Angiogenesis," appears in the March 2009 issue of the American Journal of Pathology. ...> Full Article Suppressing cancer with a master control gene (2/27/2009)Starting with the tiny fruit fly and then moving into mice and humans, researchers at VIB and K. U. Leuven show that expression of the same gene suppresses cancer in all three organisms. Reciprocally, switching off the gene -- called Ato in flies and ATOH1 in mammals -- leads to cancer. The authors show there is a good chance that the gene can be switched on again with a drug. They report their findings in two papers in the leading online open-access journal PLoS Biology. ...> Full Article Human stem cells provide a new model for Lou Gehrig's disease (2/27/2009)Motor neurons derived from embryonic stem cells mimic the progress of familial ALS ...> Full Article Enhanced skin cancer risk linked to defects in cellular aging controls (2/27/2009)Mouse model of a UV sensitivity syndrome illustrates skin stem cell dysfunction is linked to cancer pathology ...> Full Article Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses (2/26/2009)Antibodies bind to conserved region of the virus and may offer cross-protection ...> Full Article Tiny tool to control growing blood vessels opens new potential in tumor research (2/26/2009)
Malaria parasite zeroes in on molecule to enhance its survival, team finds (2/25/2009)A team of researchers from Princeton University and the Drexel University College of Medicine has found that the parasite that causes malaria breaks down an important amino acid in its quest to adapt and thrive within the human body. By depleting this substance called arginine, the parasite may trigger a more critical and deadlier phase of the disease. The work may point the way to better treatments. ...> Full Article New 'bubble' targets only cancer cells (2/25/2009)
No longer a gray area: Our hair bleaches itself as we grow older (2/24/2009)New research report in the FASEB Journal gets to the roots of gray hair ...> Full Article Team learns how cellular protein detects viruses and sparks immune response (2/24/2009)
Anti-aging pathway enhances cell stress response (2/24/2009)A Northwestern University-led research team has discovered a new molecular relationship critical to keeping cells healthy across a long span of time: a protein called SIRT1, important for caloric restriction and lifespan and activated by resveratrol, regulates heat shock factor 1 (HSF1), keeping it active. HSF1 in turn senses the presence of damaged proteins in the cell and elevates the expression of molecular chaperons to keep a cell's proteins in a folded, functional state. ...> Full Article Newly discovered gene could be a prime target in the most lethal brain cancer (2/24/2009)Scientists at Duke University Medical Center and Johns Hopkins University have discovered mutations in two genes that could become therapeutic targets in malignant glioma, a dangerous class of brain tumors. ...> Full Article High-fat diets inflame fat tissue around blood vessels, contribute to heart disease (2/23/2009)A study by researchers at the University of Cincinnati shows that high-fat diets, even if consumed for a short amount of time, can inflame fat tissue surrounding blood vessels, possibly contributing to cardiovascular disease. ...> Full Article 2 gene mutations linked to most common brain cancers -- and longer survival (2/23/2009)Scientists at the Johns Hopkins Kimmel Cancer Center and Duke University Medical Center have linked mutations in two genes, IDH1 and IDH2, to nearly three-quarters of several of the most common types of brain cancers known as gliomas. Among the findings: people with certain tumors that carry these genetic alterations appear to survive at least twice as long as those without them. ...> Full Article Scientists uncover indicator that warns leukemia is progressing to more dangerous form (2/23/2009)Scientists at the Moores Cancer Center at the University of California, San Diego, Stanford University School of Medicine and other centers have identified a mechanism by which a chronic form of leukemia can progress into a deadlier stage of the disease. The findings may provide physicians with an indicator of when this type of cancer -- chronic myeloid leukemia -- is progressing, enabling them to make more accurate prognoses for the disease and improved treatment choices. ...> Full Article Singapore research organisations team up to advance drug discovery using brain tumor stem cells (2/22/2009)A new research collaboration will leverage earlier findings that primary brain tumors are caused by minority group of cells that display genetic profile distinct from that of tumor bulk. ...> Full Article New genomic markers associated with risk of heart disease and early heart attack (2/22/2009)Five short reports published simultaneously by the journal Nature Genetics have for the first time identified clusters of genetic markers associated with heart attack and coronary heart disease. In one of the reports, from the largest ever study of its kind, the Myocardial Infarction Genetics Consortium identified nine precise genes associated with an increased risk of infarction (MI), three of them newly discovered; the investigators said that these nine gene variants "identify 20 percent of the population at 2.25-fold increased risk for MI." ...> Full Article Genetic ID of marker in lymph nodes may be linked to colorectal cancer recurrence risk (2/21/2009)A preliminary report suggests that genetic testing may help identify a marker in lymph nodes that is associated with an increased risk of colorectal cancer recurrence among patients in whom conventional testing indicates that those lymph nodes show no evidence of cancer spread, according to a study in the Feb. 18 issue of JAMA. ...> Full Article New research identifies faster detection of viruses (2/21/2009)A more specific and faster detection of viruses has been identified in new research by Trinity College Dublin's Professor of Physics, Martin Hegner at Trinity College's Center of Research on Adaptive Nanostructures and Nanodevices and an international team of researchers. These findings have been published online in Nature News and will be published in the international peer-reviewed journal Nature Nanotechnology in March. ...> Full Article Scientists uncover secrets of potential bioterror virus (2/21/2009)Major virulence factor for Rift Valley fever virus found to have dual mechanism ...> Full Article Researchers identify gene linked to aggressive progression of liver cancer (2/20/2009)Virginia Commonwealth University researchers have identified a gene that plays a key role in regulating liver cancer progression, a discovery that could one day lead to new targeted therapeutic strategies to fight the highly aggressive disease. ...> Full Article In flurry of studies, researcher details role of apples in inhibiting breast cancer (2/20/2009)Six studies published in the past year by a Cornell researcher add to growing evidence that an apple a day -- as well as daily helpings of other fruits and vegetables -- can help keep the breast-cancer doctor away. ...> Full Article Team develops nano-hydrogels capable of detecting cancer cells (2/20/2009)One of the problems in the treatment of cancers continues to be the lack of ability when it comes to discriminating between healthy and unhealthy cells, with the result being that all cells are affected non-specifically by the treatment. ...> Full Article Radioimmunotherapy: Promising treatment for HIV infection and viral cancers (2/19/2009)
New lab evidence suggests preventive effect of herbal supplement in prostate cancer (2/18/2009)DHEA is a natural circulating hormone and the body's production of it decreases with age. Men take DHEA as an over-the-counter supplement because it has been suggested that DHEA can reverse aging or have anabolic effects since it can be metabolized in the body to androgens. ...> Full Article Researchers develop new platinum-based anti-tumor compound (2/18/2009)Researchers in the Department of Chemistry at Wake Forest University in collaboration with colleagues at the Wake Forest University Health Sciences Comprehensive Cancer Center have developed a new class of platinum-based anti-tumor drugs that animal studies have shown to be 10 times more effective than current treatments in destroying certain types of lung cancer cells. ...> Full Article Stem cell research uncovers mechanism for type 2 diabetes (2/17/2009)Taking clues from their stem cell research, investigators at the University of California San Diego and Burnham Institute for Medical Research have discovered that a signaling pathway involved in normal pancreatic development is also associated with type 2 diabetes. ...> Full Article Engineers create intelligent molecules that seek-and-destroy diseased cells (2/16/2009)Current treatments for diseases like cancer typically destroy nasty malignant cells, while also hammering the healthy ones. Using new advances in synthetic biology, researchers are designing molecules intelligent enough to recognize diseased cells, leaving the healthy cells alone. "We basically design molecules that actually go into the cell and do an analysis of the cellular state before delivering the therapeutic punch," said Christina Smolke, assistant professor of bioengineering who joined Stanford University in January. ...> Full Article Nanoscopic changes to pancreatic cells reveal cancer (2/16/2009)New spectroscopy technique may help detect deadly disease early ...> Full Article Researchers find new biomarker for fatal prostate cancer (2/16/2009)New research findings out of Wake Forest University School of Medicine and the University of Wisconsin may help provide some direction for men diagnosed with prostate cancer about whether their cancer is likely to be life-threatening. ...> Full Article Novel economical blood test for hepatitis C (2/15/2009)Procedure permits mass screening of blood banks in poorer countries, too ...> Full Article 'Normalizing' tumor vessels leaves cancer more benign (2/15/2009)A report publishing online on Feb. 12 in the journal Cell, a Cell Press publication, suggests a counterintuitive new method to make cancer less likely to spread: by normalizing the shape of tumors' blood vessels to improve their oxygen supply. Such a treatment strategy might also boost the efficacy and reduce resistance to available anti-cancer drugs and so-called anti-angiogenic drugs that work by cutting off the growth of new blood vessels. ...> Full Article People who exercise lower their risk of colon cancer (2/15/2009)An ambitious new study has added considerable weight to the claim that exercise can lower the risk for colon cancer. Researchers at Washington University School of Medicine in St. Louis and Harvard University combined and analyzed several decades worth of data from past studies on how exercise affects colon cancer risk. They found that people who exercised the most were 24 percent less likely to develop the disease than those who exercised the least. ...> Full Article Bone marrow transplant patients may benefit from new immune research (2/14/2009)Bone marrow transplant researchers at the Medical College of Wisconsin Cancer Center in Milwaukee may have found a mechanism that could preserve the leukemia-killing effects of a transplant graft, while limiting the damage donor immune cells might do to the recipient host's vital organs. ...> Full Article Nanoparticle 'smart bomb' targets drug delivery to cancer cells (2/14/2009)Researchers at North Carolina State University have successfully modified a common plant virus to deliver drugs only to specific cells inside the human body, without affecting surrounding tissue. These tiny "smart bombs" -- each one thousands of times smaller than the width of a human hair -- could lead to more effective chemotherapy treatments with greatly reduced, or even eliminated, side effects. ...> Full Article A pocketful of uranium (2/14/2009)
Putting a name to the fluke (2/13/2009)In a world first, a UQ researcher has developed a non-invasive screening method for potentially fatal liver and intestinal flukes plaguing the lives of an estimated 9 million people throughout southeast Asia. ...> Full Article Camouflaging of viral DNA could be crucial step in progression of cancers (2/12/2009)15 percent of cancers can be linked to a viral infection. However, the biological changes that cause some asymptomatic carriers of a virus to develop malignancies are not well understood. In a study published online in Genome Research, scientists mapped a chemical modification of DNA in Epstein-Barr, human papilloma and hepatitis B viruses and found that the viral genomes undergo changes during the progression of disease, with implications for new prevention, diagnosis and treatment strategies. ...> Full Article Researchers discover metabolite linked to aggressive prostate cancer (2/12/2009)Finding could lead to test to help guide treatment decisions ...> Full Article New study compares avian flu with a notorious killer from the past (2/11/2009)
First genome-wide expression analysis yields better understanding of how leukemia develops (2/11/2009)In a collaborative study published Feb. 9, 2009, in the Proceedings of the National Academy of Sciences, scientists performed a genome-wide expression analysis comparing highly enriched normal blood stem cells and leukemic stem cells, and identified several new pathways that have a key role in cancer development. ...> Full Article Effects of smoking linked to accelerated aging protein (2/10/2009)
Arginine discovery could help fight human obesity (2/10/2009)A Texas AgriLife Research scientist and fellow researchers have discovered that arginine, an amino acid, reduces fat mass in diet-induced obese rats and could help fight human obesity. ...> Full Article Scientists create first crystal structure of an intermediate particle in virus assembly (2/10/2009)A research team at the Scripps Research Institute has been able to produce the first crystal structure of a virus particle caught in the midst of assembling its impenetrable outer protein coat. ...> Full Article Marijuana use linked to increased risk of testicular cancer (2/10/2009)Risk appears to be elevated particularly among frequent and/or long-term users ...> Full Article New findings reveal how influenza virus hijacks human cells (2/10/2009)
Heart failure linked to cognitive impairment (2/9/2009)Memory and other problems may affect care of heart failure patients, suggests study in Journal of Cardiac Failure. ...> Full Article Scientists discover how deadly fungus protects itself (2/8/2009)
Tobacco smoke and alcohol harm liver worse as combo (2/8/2009)Mice exposed to secondhand smoke and who drank ethanol had 110 percent more liver fibrosis proteins than mice who breathed filtered air, according to the findings of a new study. Elevated risk of liver disease is now added to mounting evidence that tobacco smoke and alcohol are worse for health as a combination, beyond the individual exposure risks, researchers said. ...> Full Article Molecule that suppresses immune response under study in type 1 diabetes (2/8/2009)
Source of cancer stem cells' resistance to radiation discovered at Stanford (2/8/2009)Much to the dismay of patients and physicians, cancer stem cells -- tiny powerhouses that generate and maintain tumor growth in many types of cancers -- are relatively resistant to the ionizing radiation often used as therapy for these conditions. ...> Full Article Inflammation in colon may get doused before fueling cancer development (2/7/2009)Repeated inflammation that leads to colon cancer may have met its match. A tiny molecule, quercetin, found in most plant-based foods douses the flames before damaging lesions can form in the colon, says Dr. Nancy Turner, Texas AgriLife Research scientist. And the nice thing is that quercetin is readily available in common plant-based foods. So it's not an unachievable goal for us good ol' Americans if we do the right thing with our food consumption. ...> Full Article Living longer thanks to the 'longevity gene' (2/7/2009)Kiel scientists prove that 100-year-old Europeans carry a special sequence variation of the FOXO3A gene ...> Full Article Scientists develop crystal ball for personalized cancer treatment (2/7/2009)New tool predicts how a chemotherapy drug will work on individual tumor ...> Full Article Gene expression signature associated with survival in advanced ovarian cancer (2/7/2009)A new study published this week in the open-access journal PLoS Medicine identifies molecular pathways associated with outcomes in ovarian cancer. Currently, outcomes following diagnosis of ovarian cancer are very poor, with up to 65-70 percent of women dying within five years of diagnosis. ...> Full Article Can cannibalism fight infections? (2/7/2009)
Gene mutations increase risk for aggressive prostate cancer (2/6/2009)
Stroma genomic signature predicts resistance to anthracyclin-based chemotherapy in breast cancer (2/6/2009)1 step closer to personalized medicine ...> Full Article Bone marrow cells can heal nerves in diabetes model (2/6/2009)Many people with diabetes have damage to the nerves. Cells derived from the bone marrow can both promote the regrowth of blood vessels and prevent the ongoing loss (or death) of the protective lining of nerves in the limbs of diabetic animals. The bone marrow cells appear to home to peripheral nerves and remain engrafted for weeks. ...> Full Article Dry beans inhibit development of mammary cancer (2/6/2009)With increasing interest in the ways certain food can reduce people's risks for contracting chronic diseases, a new study demonstrates the benefits of dry beans in reducing the risk of contracting mammary cancer, due to their levels of antioxidants and other cancer reducing contents. ...> Full Article Rare skin tumor responds better to treatment than melanoma (2/6/2009)A team of Vanderbilt University Medical Center investigators has developed a group of chemical compounds -- the first selective inhibitors of the protein phospholipase D -- that could represent a new class of drugs for treating cancer.The new inhibitors, reported in the February issue of Nature Chemical Biology, block the invasive migration of breast cancer cells, supporting their further development as antimetastatic agents. ...> Full Article Compounds could be new class of cancer drugs (2/5/2009)A team of Vanderbilt University Medical Center investigators has developed a group of chemical compounds -- the first selective inhibitors of the protein phospholipase D -- that could represent a new class of drugs for treating cancer.The new inhibitors, reported in the February issue of Nature Chemical Biology, block the invasive migration of breast cancer cells, supporting their further development as antimetastatic agents. ...> Full Article Targeted nanospheres find, penetrate, then fuel burning of melanoma (2/5/2009)
Stat3 signaling tips the balance of immunity in favor of cancer (2/5/2009)New research reveals how a cancer-associated protein enables tumor cells to evade the immune system by both suppressing anti-tumor influences and promoting tumor-enhancing conditions, in essence turning the immune system to the dark side of the force. The study is published by Cell Press in the Feb. 3 issue of the journal Cancer Cell. ...> Full Article Inflammation directly linked to colon cancer (2/5/2009)While chronic inflammation is believed to be a predisposing factor for colon cancer, exact mechanisms linking these conditions remain elusive. Scientists at the Melbourne Branch of the international Ludwig Institute for Cancer Research and the Technical University Munich have jointly discovered a new piece of this puzzle by demonstrating how the Stat3 protein links inflammation to tumor development, a discovery that may well lead to the identification of new therapeutic targets for colon cancer. ...> Full Article Household chemicals may be linked to infertility (2/4/2009)Researchers at the UCLA School of Public Health have found the first evidence that perfluorinated chemicals -- chemicals that are widely used in everyday items such as food packaging, pesticides, clothing, upholstery, carpets and personal care products -- may be associated with infertility in women. ...> Full Article Researchers disrupt biochemical system involved in cancer, degenerative disease (2/4/2009)
Single gene lets bacteria jump from host to host (2/4/2009)All life -- plants, animals, people -- depends on peaceful coexistence with a swarm of microbial life that performs vital services from helping to convert food to energy to protection from disease. ...> Full Article New clues to pancreatic cells' destruction in diabetes (2/4/2009)Researchers have found what appears to be a major culprit behind the loss of insulin-producing b cells from the pancreases of people with diabetes, a critical event in the progression of the disease. ...> Full Article Stress may hasten the growth of melanoma tumors (2/3/2009)But common beta-blocker medications might slow that progress ...> Full Article Worm provides clues about preventing damage caused by low-oxygen during stroke, heart attack (2/3/2009)Neurobiologists at Washington University School of Medicine in St. Louis have identified pathways that allow microscopic worms to survive in a low-oxygen, or hypoxic, environment. They believe the finding could have implications for conditions such as stroke, heart attack and cancer. Sensitivity to low oxygen helps determine how damaging those medical conditions can be. ...> Full Article New research findings may enable earlier diagnosis of uterine cancer (2/3/2009)Cancer of the uterus (womb) is the most common gynecological malignancy in the West. Research carried out at the University of Gothenburg, Sweden, has now identified a gene that may simplify future diagnosis. ...> Full Article Skin color studies on tadpoles lead to cancer advance (2/2/2009)The humble tadpole could provide the key to developing effective anti-skin cancer drugs, thanks to a groundbreaking discovery by researchers at the University of East Anglia. ...> Full Article Sequential and alternating chemotherapy and radiation equally effective in larynx cancer therapy (2/2/2009)Larynx cancer patients treated with alternating cycles of chemotherapy and radiation have similar outcomes to patients treated with chemotherapy followed by radiation, according to data from a randomized controlled trial in the Jan. 27 online issue of the Journal of the National Cancer Institute. ...> Full Article Spinal fluid proteins signal Lou Gehrig's disease (2/1/2009)High levels of certain proteins in the spinal fluid could signal the onset of Lou Gehrig's disease, according to researchers. The discovery of these biomarkers may lead to diagnostic kits for early diagnosis, accurately measuring the progression of the disease and monitoring the effects of treatment. ...> Full Article Scientists make malaria parasite work to reveal its own vulnerabilities (2/1/2009)Researchers seeking ways to defeat malaria have found a way to get help from the parasite that causes the disease. Scientists at Washington University School of Medicine in St. Louis stepped aside and let Plasmodium falciparum, one of the deadliest strains of malaria, do a significant portion of the genetic engineering work in their new study. ...> Full Article |
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New testing method hints at garlic's cancer-fighting potential
New biomarkers for predicting the spread of colon cancer
Cells of aggressive leukemia hijack normal protein to grow
The sound of melanoma can help doctors find cancer
Bitter melon extract attacks breast cancer cells
Scanning for skin cancer: Infrared system looks for deadly melanoma