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Glucosamine promotes longevity by mimicking a low-carb diet (4/9/2014)

The widely used food supplement glucosamine promotes longevity in aging mice by approximately 10 percent due to improved glucose metabolism. Michael Ristow, M.D., a professor at ETH Zurich, and his team find that the compound does so 'by mimicking a low-carb diet in elderly mice reflecting human retirees.' ...> Full Article


Monkey caloric restriction study shows big benefit; contradicts earlier study (4/2/2014)

Monkey caloric restriction study shows big benefit; contradicts earlier studyThe latest results from a 25-year study of diet and aging in monkeys shows a significant reduction in mortality and in age-associated diseases among those with calorie-restricted diets. The study, begun at the University of Wisconsin-Madison in 1989, is one of two ongoing, long-term US efforts to examine the effects of a reduced-calorie diet on nonhuman primates. ...> Full Article


Drilling into the trends in genetics and epigenetics of aging and longevity (3/30/2014)

An international group of scientists performed a comprehensive analysis of the genetic and epigenetic mechanisms and demonstrated that the majority of the genes, as well as genetic and epigenetic mechanisms that are involved in regulation of longevity, are highly interconnected and related to stress response. Also, for the first time, the group performed a comprehensive analysis of government research grants related to the genes involved in aging. ...> Full Article


Deletion of FAT10 gene reduces body fat, slows down aging in mice (3/26/2014)

A single gene appears to play a crucial role in coordinating the immune system and metabolism, and deleting the gene in mice reduces body fat and extends lifespan, according to new research by scientists at the Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University and Yale University School of Medicine. ...> Full Article


Less is more: New theory on why very low nutrient diets can extend lifespan (3/20/2014)

UNSW scientists have developed a new evolutionary theory on why consuming a diet that is very low in nutrients extends lifespan in laboratory animals -- research that could hold clues to promoting healthier aging in humans. The study is published in the journal BioEssays. ...> Full Article


Eat more, die young: Why eating a diet very low in nutrients can extend lifespan (3/19/2014)

A new evolutionary theory in BioEssays claims that consuming a diet very low in nutrients can extend lifespan in laboratory animals, a finding which could hold clues to promoting healthier aging in humans. ...> Full Article


Human Longevity Inc. (HLI) Launched to Promote Healthy Aging Using Advances in Genomics and Stem Cell Therapies (3/19/2014)

Human Longevity Inc. (HLI) Launched to Promote Healthy Aging Using Advances in Genomics and Stem Cell TherapiesHLI is Building World's Largest Genotype/Phenotype Database by Sequencing up to 40,000 Human Genomes/Year Combined with Microbiome, Metabolome and Clinical Data to Develop Life Enhancing Therapies. HLI has Purchased Two Illumina HiSeq X Ten Sequencing Systems. ...> Full Article


Longevity mutation found in flies far and wide (2/9/2014)

Longevity mutation found in flies far and wideTo date, evidence that mutations in a gene called Indy could increase life span in flies and mimic calorie restriction in mammals has come only from experiments in the lab. A new study finds that the same benefit is present in naturally Indy-mutated flies descended from flies collected in the wild all over the world and going back decades. ...> Full Article


Cell cycle speed is key to making aging cells young again (1/31/2014)

Yale School of Medicine researchers identified a major obstacle to converting cells back to their youthful state -- the speed of the cell cycle, or the time required for a cell to divide. When the cell cycle accelerates to a certain speed, the barriers that keep a cell's fate on one path diminish. In such a state, cells are easily persuaded to change their identity and become pluripotent, or capable of becoming multiple cell types. ...> Full Article


Scientists find genetic mechanism linking aging to specific diets (1/28/2014)

In new research published this month in Cell Metabolism, USC scientists Sean Curran and Shanshan Pang identify a collection of genes that allow an organism to adapt to different diets and show that without them, even minor tweaks to diet can cause premature aging and death. ...> Full Article


Altering the community of gut bacteria promotes health and increases lifespan (1/17/2014)

Having the right balance of gut bacteria may be the key to enjoying a long healthy life. Scientists at the Buck Institute promoted health and increased lifespan in Drosophila by altering the symbiotic relationship between bacteria and the absorptive cells lining the intestine. The work provides a model for studying diseases associated with the aging gut, and how we go from having a young, healthy gut to one that is old and decrepit. ...> Full Article


Turning off the 'aging genes' (1/6/2014)

Restricting calorie consumption is one of the few proven ways to combat aging. Now Tel Aviv University has developed a computer algorithm that predicts which genes can be "turned off" to create the same anti-aging effect as calorie restriction. The findings could lead to the development of new drugs to treat aging. ...> Full Article


A new -- and reversible -- cause of aging (12/23/2013)

Researchers have discovered a cause of aging in mammals involving a series of molecular events that disables communication between the nucleus and mitochondria. By administering a molecule naturally produced by the human body, the communication network was restored in older mice. Subsequent tissue samples showed biological hallmarks comparable to much younger animals. ...> Full Article


Parasitic DNA proliferates in aging tissues (12/21/2013)

Parasitic DNA proliferates in aging tissuesAs mice age, cells in tissues such as the liver and skeletal muscle lose control over rogue sequences of DNA called "retrotransposable elements," according to new research in the journal Aging. The elements, which may undermine health, were able to proliferate in old mice and were also abundant in cancerous tissue. A low-calorie diet, however, restrained their advance. ...> Full Article


Combining mutants results in 5-fold lifespan extension in C. elegans (12/14/2013)

What are the limits to longevity? Scientists at the Buck Institute combined mutations in two pathways well-known for lifespan extension and report a synergistic five-fold lifespan extension in the nematode C. elegans. The worms lived to the human equivalent of 400 to 500 years. The research introduces the possibility of combination therapy for aging and could help explain why scientists are having a difficult time identifying single genes responsible for long lives in human centenarians. ...> Full Article

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New Articles
Glucosamine promotes longevity by mimicking a low-carb diet

Monkey caloric restriction study shows big benefit; contradicts earlier studyMonkey caloric restriction study shows big benefit; contradicts earlier study

Drilling into the trends in genetics and epigenetics of aging and longevity

Deletion of FAT10 gene reduces body fat, slows down aging in mice

Less is more: New theory on why very low nutrient diets can extend lifespan

Eat more, die young: Why eating a diet very low in nutrients can extend lifespan

Human Longevity Inc. (HLI) Launched to Promote Healthy Aging Using Advances in Genomics and Stem Cell TherapiesHuman Longevity Inc. (HLI) Launched to Promote Healthy Aging Using Advances in Genomics and Stem Cell Therapies

Longevity mutation found in flies far and wideLongevity mutation found in flies far and wide

Cell cycle speed is key to making aging cells young again

Scientists find genetic mechanism linking aging to specific diets

Altering the community of gut bacteria promotes health and increases lifespan

Turning off the 'aging genes'

A new -- and reversible -- cause of aging

Parasitic DNA proliferates in aging tissuesParasitic DNA proliferates in aging tissues

Combining mutants results in 5-fold lifespan extension in C. elegans



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